Scholarlink

<p>Radiofrequency ablation (RFA) is a minimally invasive technique that is increasingly applied in endocrine diseases. While parathyroidectomy (PTX) is the first-line treatment for primary hyperparathyroidism (PHPT) and the standard option for secondary hyperparathyroidism (SHPT) unresponsive to medical therapy, RFA is under investigation as an alternative for high-risk or non-surgical candidates. This review included 31 studies, six of which were meta-analyses, assessing RFA in PHPT, SHPT, and tertiary hyperparathyroidism (THPT). In PHPT, complete response rates ranged from 60% to 100%, with volume reduction ratios exceeding 95%. A frequent observation was eucalcemic PTH elevation, attributed to bone turnover or release of glandular suppression, though usually without clinical consequences. In SHPT, outcomes were variable, and further investigation is required before establishing RFA as a therapeutic approach. Compared with PTX, RFA demonstrated lower rates of severe hypocalcemia and shorter recovery, though PTX achieved stronger biochemical suppression. Complications were generally mild and transient, most often hypocalcemia or hoarseness. RFA in PHPT may be used in patients not suitable for surgery under general anaesthesia. The technique should be used only as a unilateral approach whereas in bilateral hyperplasia associated with SHPT can be hazardous. Larger series are necessary to establish the RFA technique and clarify the recurrent laryngeal nerve paresis and long-term results.</p>

错误：搜索内容不能为空，请输入英文关键词
错误：关键词超出字数限制，请精简
高级检索

Radiofrequency ablation as an alternative treatment for hyperparathyroidism: a case study of a single parathyroid adenoma and review of the literature

  • 期刊论文

  • 发表日期：

    2026年3月26日

查看全文
  • Maria Chrysoula Tatarida Palla,
  • Aspasia Drosou,
  • Pyrros Gkousis,
  • Anna Drakopoulou,
  • Styliani Kalaitzidou,
  • Eirini Veniou,
  • Myrsini Gkeli

摘要

Radiofrequency ablation (RFA) is a minimally invasive technique that is increasingly applied in endocrine diseases. While parathyroidectomy (PTX) is the first-line treatment for primary hyperparathyroidism (PHPT) and the standard option for secondary hyperparathyroidism (SHPT) unresponsive to medical therapy, RFA is under investigation as an alternative for high-risk or non-surgical candidates. This review included 31 studies, six of which were meta-analyses, assessing RFA in PHPT, SHPT, and tertiary hyperparathyroidism (THPT). In PHPT, complete response rates ranged from 60% to 100%, with volume reduction ratios exceeding 95%. A frequent observation was eucalcemic PTH elevation, attributed to bone turnover or release of glandular suppression, though usually without clinical consequences. In SHPT, outcomes were variable, and further investigation is required before establishing RFA as a therapeutic approach. Compared with PTX, RFA demonstrated lower rates of severe hypocalcemia and shorter recovery, though PTX achieved stronger biochemical suppression. Complications were generally mild and transient, most often hypocalcemia or hoarseness. RFA in PHPT may be used in patients not suitable for surgery under general anaesthesia. The technique should be used only as a unilateral approach whereas in bilateral hyperplasia associated with SHPT can be hazardous. Larger series are necessary to establish the RFA technique and clarify the recurrent laryngeal nerve paresis and long-term results.