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<p>An ageing-related pathology has recently been described as one that develops and/or progresses with increasing chronological age, that is associated with, or contributes to, functional decline and that is evidenced by studies in humans. The pineal gland is a photo-neuroendocrine organ whose primary function is to produce and secrete melatonin in response to light-dark cycle environmental cues. The gland may undergo ageing-related structural and morphological changes, including calcification, gliosis, cyst formation, and reduced density of β-adrenergic receptors, which are hypothesised to reduce melatonin secretion. Pineal gland senescence describes the ageing-related decline in neuroendocrine function, with reduced secretion of melatonin, which may contribute to ageing-related sleep disorders and disruption of other circadian-driven physiological functions and may have secondary effects such as contributing to cognitive and mood disorders related to sleep disturbance.</p>

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Pineal gland senescence: an emerging ageing-related pathology?

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2025年12月16日

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  • Emma Short,
  • Ramzi Ajjan,
  • Thomas M Barber,
  • Sunil Bhandari,
  • Paul Chazot,
  • Jennifer L. Garrison,
  • Anushka Goyal,
  • Robert Huckstepp,
  • Noordin Jamal,
  • Venkateswarlu Kanamarlapudi,
  • Alpar Lazar,
  • Thomas Lee,
  • Adriana A. S. Tavares,
  • Jeremy J Tree,
  • Jack Wellington,
  • Stuart RG Calimport,
  • Barry Bentley

摘要

An ageing-related pathology has recently been described as one that develops and/or progresses with increasing chronological age, that is associated with, or contributes to, functional decline and that is evidenced by studies in humans. The pineal gland is a photo-neuroendocrine organ whose primary function is to produce and secrete melatonin in response to light-dark cycle environmental cues. The gland may undergo ageing-related structural and morphological changes, including calcification, gliosis, cyst formation, and reduced density of β-adrenergic receptors, which are hypothesised to reduce melatonin secretion. Pineal gland senescence describes the ageing-related decline in neuroendocrine function, with reduced secretion of melatonin, which may contribute to ageing-related sleep disorders and disruption of other circadian-driven physiological functions and may have secondary effects such as contributing to cognitive and mood disorders related to sleep disturbance.