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Purpose <p>We investigated the association between multimorbidity level, all-cause 30-day readmissions, and post-discharge 30-day mortality.</p> Methods <p>Using Danish national registries, we identified patients aged ≥ 65&#xa0;years hospitalized for ambulatory care-sensitive conditions between 2013–2018. Multimorbidity was defined as having 2–3 (moderate) or ≥ 4 (severe) of 39 chronic conditions. We estimated 30-day cumulative incidence of readmission after discharge and used Cox regression to calculate hazard ratios (HRs) for readmission and mortality.</p> Results <p>Among 178,445 patients, median age was 78&#xa0;years (IQR: 71–85), 59% were female. The 30-day readmission rate was 21% for those with severe multimorbidity, compared with 12% for those without multimorbidity and 16% for those with moderate multimorbidity. The hazard of 30-day readmission was elevated for both moderate (HR 1.4, 95% CI 1.4–1.5) and severe (HR 1.9, 95% CI 1.8–1.9) multimorbidity. Additionally, moderate and severe multimorbidity were associated with increased 30-day mortality (HR 1.9, 95% CI 1.7–2.1 and HR 2.6, 95% CI 2.4–2.8, respectively).</p> Conclusion <p>Multimorbidity is associated with increased risk of hospital readmission and mortality, underscoring the need for improved care coordination in acute and post-discharge settings.</p>

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Multimorbidity, readmissions and mortality among older patients with potentially preventable hospitalisations: a Danish nationwide cohort study

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2026年5月19日

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  • Trine Worm Thøgersen,
  • Eskild Bendix Kristiansen,
  • Katrine Bødkergaard,
  • Mette Geil Kollerup,
  • Deirdre Cronin-Fenton,
  • Marianne Lisby

摘要

Purpose

We investigated the association between multimorbidity level, all-cause 30-day readmissions, and post-discharge 30-day mortality.

Methods

Using Danish national registries, we identified patients aged ≥ 65 years hospitalized for ambulatory care-sensitive conditions between 2013–2018. Multimorbidity was defined as having 2–3 (moderate) or ≥ 4 (severe) of 39 chronic conditions. We estimated 30-day cumulative incidence of readmission after discharge and used Cox regression to calculate hazard ratios (HRs) for readmission and mortality.

Results

Among 178,445 patients, median age was 78 years (IQR: 71–85), 59% were female. The 30-day readmission rate was 21% for those with severe multimorbidity, compared with 12% for those without multimorbidity and 16% for those with moderate multimorbidity. The hazard of 30-day readmission was elevated for both moderate (HR 1.4, 95% CI 1.4–1.5) and severe (HR 1.9, 95% CI 1.8–1.9) multimorbidity. Additionally, moderate and severe multimorbidity were associated with increased 30-day mortality (HR 1.9, 95% CI 1.7–2.1 and HR 2.6, 95% CI 2.4–2.8, respectively).

Conclusion

Multimorbidity is associated with increased risk of hospital readmission and mortality, underscoring the need for improved care coordination in acute and post-discharge settings.