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Purpose <p>Frailty affects between 20 and 75% of residents in long-term care facilities; however, there is a notable absence of objective biological assessment tools for proactive risk stratification.</p> Methods <p>To address this gap, we examined inflammatory and metabolic biomarkers using a validated 52-item Frailty Index in a cohort of 292 older adults residing in institutions. Each participant completed an assessment of the Frailty Index and underwent quantification of 12 inflammatory and metabolic-nutritional biomarkers that encompass the pathways of inflammation, proteostasis, and metabolic dysregulation.</p> Results <p>In a study of 292 institutionalized older adults (mean age 82.6 ± 6.7 years, 68.8% female, 58.6% frail), a simplified three-biomarker panel—interleukin-6 (IL-6), prealbumin, and high-sensitivity C-reactive protein (hs-CRP)—demonstrated excellent predictive accuracy. A simplified three-biomarker panel—interleukin-6 (IL-6), prealbumin, and high-sensitivity C-reactive protein (hs-CRP)achieved excellent diagnostic accuracy (area under curve (AUC) = 0.861, 95% confidence interval (CI) 0.801–0.915), with 81.2% sensitivity and 85.4% specificity for This parsimonious panel retained 96.5% of the predictive performance of the full 12-biomarker model while using only routinely available laboratory tests.</p> Conclusion <p>Taken together, these results underscore the potential of inflammatory and metabolic biomarkers for the early identification of high-risk residents, thereby supporting personalized nursing care. Integrating biomarker-guided stratification may facilitate the targeted allocation of nutritional support, physical therapy, and inflammatory management, potentially preventing 30–40% of frailty progression.</p>

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A three-biomarker panel for frailty prediction and risk stratification in institutionalized older adults: a multicenter validation study

  • 期刊论文

  • 发表日期：

    2026年4月9日

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  • Amr Ali Mohamed Abdelgawwad El-Sehrawy,
  • Ismail Abdelhameed Abadia Ali Kandi,
  • Mansuor A. Alanazi,
  • Saud S. Alharbi,
  • Sultan Mohammed Alanazi,
  • Mona Y. Alqassim,
  • Amal A. Abdulbaqi,
  • Amro Elbaz

摘要

Purpose

Frailty affects between 20 and 75% of residents in long-term care facilities; however, there is a notable absence of objective biological assessment tools for proactive risk stratification.

Methods

To address this gap, we examined inflammatory and metabolic biomarkers using a validated 52-item Frailty Index in a cohort of 292 older adults residing in institutions. Each participant completed an assessment of the Frailty Index and underwent quantification of 12 inflammatory and metabolic-nutritional biomarkers that encompass the pathways of inflammation, proteostasis, and metabolic dysregulation.

Results

In a study of 292 institutionalized older adults (mean age 82.6 ± 6.7 years, 68.8% female, 58.6% frail), a simplified three-biomarker panel—interleukin-6 (IL-6), prealbumin, and high-sensitivity C-reactive protein (hs-CRP)—demonstrated excellent predictive accuracy. A simplified three-biomarker panel—interleukin-6 (IL-6), prealbumin, and high-sensitivity C-reactive protein (hs-CRP)achieved excellent diagnostic accuracy (area under curve (AUC) = 0.861, 95% confidence interval (CI) 0.801–0.915), with 81.2% sensitivity and 85.4% specificity for This parsimonious panel retained 96.5% of the predictive performance of the full 12-biomarker model while using only routinely available laboratory tests.

Conclusion

Taken together, these results underscore the potential of inflammatory and metabolic biomarkers for the early identification of high-risk residents, thereby supporting personalized nursing care. Integrating biomarker-guided stratification may facilitate the targeted allocation of nutritional support, physical therapy, and inflammatory management, potentially preventing 30–40% of frailty progression.