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Background <p>Vitamin D deficiency is highly prevalent among older adults with hip fracture and may compromise recovery. This study evaluated the effectiveness of two calcifediol supplementation regimens in correcting serum 25-hydroxyvitamin D [25(OH)D] levels and supporting functional recovery.</p> Methods <p>In this randomized clinical trial, 50 patients aged ≥ 75&#xa0;years with hip fracture and serum 25(OH)D &lt; 30&#xa0;ng/mL were assigned to receive calcifediol 266&#xa0;μg daily for 5&#xa0;days (intervention group, IG) or 266&#xa0;μg weekly for 5&#xa0;weeks (control group, CG). Primary endpoints were the proportion achieving 25(OH)D &gt; 30&#xa0;ng/mL, change in parathyroid hormone, and functional recovery assessed at discharge and at 3, 6, and 12&#xa0;months post-fracture.</p> Results <p>The mean age was 86&#xa0;years; 64% were women. Baseline 25(OH)D was 13.3&#xa0;ng/mL in the IG and 12.0&#xa0;ng/mL in the CG. After one month, both groups showed increased concentrations (38.2 vs. 35.2&#xa0;ng/mL; <i>p</i> = 0.50). PTH decreased more in the IG (43.5 vs. 75.2&#xa0;pg/mL; <i>p</i> = 0.001). Approximately 50% of patients showed clinically meaningful functional improvement. Multivariate analysis indicated lower relative functional gain in CG participants who did not achieve optimal 25(OH)D levels (67.2 vs. 43.7; <i>p</i> = 0.06). No significant differences in long-term functional outcomes were observed between groups.</p> Conclusions <p>Both daily and weekly calcifediol regimens effectively corrected vitamin D deficiency in older adults with hip fracture. Functional improvement at discharge was observed in both groups and was clinically relevant.</p> <p>Trial registration: ClinicalTrials.gov Identifier: NCT03213886 (Date of registration: 11/07/2017).</p>

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Efficacy of two calcifediol supplementation regimens in older adults post-hip fracture surgery. A clinical trial

  • 期刊论文

  • 发表日期：

    2025年9月15日

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  • Leonor Cuadra-Llopart,
  • Antoni Salvà Casanovas,
  • Georgina Cerdà Mas,
  • Esther Jovell-Fernández

摘要

Background

Vitamin D deficiency is highly prevalent among older adults with hip fracture and may compromise recovery. This study evaluated the effectiveness of two calcifediol supplementation regimens in correcting serum 25-hydroxyvitamin D [25(OH)D] levels and supporting functional recovery.

Methods

In this randomized clinical trial, 50 patients aged ≥ 75 years with hip fracture and serum 25(OH)D < 30 ng/mL were assigned to receive calcifediol 266 μg daily for 5 days (intervention group, IG) or 266 μg weekly for 5 weeks (control group, CG). Primary endpoints were the proportion achieving 25(OH)D > 30 ng/mL, change in parathyroid hormone, and functional recovery assessed at discharge and at 3, 6, and 12 months post-fracture.

Results

The mean age was 86 years; 64% were women. Baseline 25(OH)D was 13.3 ng/mL in the IG and 12.0 ng/mL in the CG. After one month, both groups showed increased concentrations (38.2 vs. 35.2 ng/mL; p = 0.50). PTH decreased more in the IG (43.5 vs. 75.2 pg/mL; p = 0.001). Approximately 50% of patients showed clinically meaningful functional improvement. Multivariate analysis indicated lower relative functional gain in CG participants who did not achieve optimal 25(OH)D levels (67.2 vs. 43.7; p = 0.06). No significant differences in long-term functional outcomes were observed between groups.

Conclusions

Both daily and weekly calcifediol regimens effectively corrected vitamin D deficiency in older adults with hip fracture. Functional improvement at discharge was observed in both groups and was clinically relevant.

Trial registration: ClinicalTrials.gov Identifier: NCT03213886 (Date of registration: 11/07/2017).