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Aim <p>To assess the relation between pre-frailty and frailty, and its components on one hand and the presence, degree and components of cognitive impairment.</p> Methods <p>This is a nationwide epidemiologic survey of health determinants in older Poles (PolSenior2). We assessed physical frailty using the approach by Fried et al. and cognitive impairment with the Mini-Mental Status Examination (MMSE). We calculated population estimates (95% CI) of conditions under study, with sampling weights to account for the complex survey design, with the age–sex post-stratification matching to the population of Poland. We used logistic regression to model cognitive impairment as function of frailty phenotype. </p> Results <p>Mean (SD) age of 5378 participants (58.0% women) was 75.0 (9.4) years. Frailty was diagnosed in 23.5% of respondents, and 54.6% were pre-frail. Normal cognition was found in 51.3%, 23.0% had suspected mild cognitive impairment (MCI), and suspected: 16.3% mild, 6.5% moderate and 2.9% severe dementia. Robust phenotype was present in 35.7% normal cognition persons, 4.7% in moderate dementia, and 0.0% in severe dementia. Frailty increased from 9.2% in normal cognition to 57.4% and 85.3% in moderate dementia and severe dementia. Frailty component that was associated with abnormalities in all MMSE domains was exhaustion. In the presence of exhaustion, the best-preserved function was registration, and the most pronounced was attention deficit.</p> Conclusion <p>Frailty and cognitive impairment are closely associated. While exhaustion was standing out among the frailty components, it was associated with impaired orientation and attention deficits. These data may inform both the prevention and rehabilitation and nutritional counseling.</p>

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The cross-sectional relationship of physical frailty and cognitive impairment in older Poles: analysis of the PolSenior2 data

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2025年5月17日

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  • Anna Skalska,
  • Karolina Piotrowicz,
  • Hanna Kujawska-Danecka,
  • Kacper Jagiełło,
  • Alicja Klich Rączka,
  • Małgorzata Mossakowska,
  • Tomasz Zdrojewski,
  • Tomasz Grodzicki,
  • Jerzy Gąsowski

摘要

Aim

To assess the relation between pre-frailty and frailty, and its components on one hand and the presence, degree and components of cognitive impairment.

Methods

This is a nationwide epidemiologic survey of health determinants in older Poles (PolSenior2). We assessed physical frailty using the approach by Fried et al. and cognitive impairment with the Mini-Mental Status Examination (MMSE). We calculated population estimates (95% CI) of conditions under study, with sampling weights to account for the complex survey design, with the age–sex post-stratification matching to the population of Poland. We used logistic regression to model cognitive impairment as function of frailty phenotype.

Results

Mean (SD) age of 5378 participants (58.0% women) was 75.0 (9.4) years. Frailty was diagnosed in 23.5% of respondents, and 54.6% were pre-frail. Normal cognition was found in 51.3%, 23.0% had suspected mild cognitive impairment (MCI), and suspected: 16.3% mild, 6.5% moderate and 2.9% severe dementia. Robust phenotype was present in 35.7% normal cognition persons, 4.7% in moderate dementia, and 0.0% in severe dementia. Frailty increased from 9.2% in normal cognition to 57.4% and 85.3% in moderate dementia and severe dementia. Frailty component that was associated with abnormalities in all MMSE domains was exhaustion. In the presence of exhaustion, the best-preserved function was registration, and the most pronounced was attention deficit.

Conclusion

Frailty and cognitive impairment are closely associated. While exhaustion was standing out among the frailty components, it was associated with impaired orientation and attention deficits. These data may inform both the prevention and rehabilitation and nutritional counseling.