<p>We describe the integration of a minimally modified household air fryer into flow chemistry experiments as a safe and cost-effective platform for conducting esterification reactions at the undergraduate and high school levels. By leveraging the continuous processing principles of flow chemistry alongside the controlled heating capabilities of an air fryer, students can efficiently synthesize esters from readily available carboxylic acids and alcohols in the absence of other solvents and with minimal workup (phase separation from an aqueous solution, washings) in good isolated yields (typically well over 50%) and high purity (&gt; 95%, as shown by <sup>1</sup>H NMR spectra of the crude isolated products). This affordable low-tech setup offers a practical and engaging demonstration of organic synthesis and flow chemistry, making it well-suited for instructional use in both secondary and post-secondary educational settings.</p> Graphical abstract <p></p>

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Bringing flow chemistry to the teaching laboratory: an air fryer as heater in simple flow chemistry esterifications

  • Nabyl Merbouh,
  • Andrew P. Chen,
  • Charlie I. Porter,
  • Namiko E. Leznoff,
  • Ali Arshad,
  • Ken Van Wieren,
  • Christian Brückner

摘要

We describe the integration of a minimally modified household air fryer into flow chemistry experiments as a safe and cost-effective platform for conducting esterification reactions at the undergraduate and high school levels. By leveraging the continuous processing principles of flow chemistry alongside the controlled heating capabilities of an air fryer, students can efficiently synthesize esters from readily available carboxylic acids and alcohols in the absence of other solvents and with minimal workup (phase separation from an aqueous solution, washings) in good isolated yields (typically well over 50%) and high purity (> 95%, as shown by 1H NMR spectra of the crude isolated products). This affordable low-tech setup offers a practical and engaging demonstration of organic synthesis and flow chemistry, making it well-suited for instructional use in both secondary and post-secondary educational settings.

Graphical abstract