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<p>Advances in gene sequencing technologies have rapidly expanded our understanding of the human microbiome. The microbiome of the female genital tract is now well characterized, revealing distinct differences between the lower and upper genital tract. The vaginal microbiome is typically dominated by <i>Lactobacillus</i> species. In contrast, the endometrial microbiome shows reduced <i>Lactobacillus</i> abundance and greater microbial diversity. Studies involving infertile couples have demonstrated a positive correlation between the presence of <i>Lactobacillus</i>, particularly <i>L. crispatus</i>, and higher pregnancy and live birth rates. However, little is currently known about the interaction between the microbiome and the immunome in the female genital tract. Research in this area faces several challenges and requires standardized protocols to ensure comparability across studies.</p>

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Das Mikrobiom des weiblichen Genitaltraktes und seine Rolle bei Infertilität

  • 期刊论文

  • 发表日期：

    2025年7月16日

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  • Rebecca Moffat

摘要

Advances in gene sequencing technologies have rapidly expanded our understanding of the human microbiome. The microbiome of the female genital tract is now well characterized, revealing distinct differences between the lower and upper genital tract. The vaginal microbiome is typically dominated by Lactobacillus species. In contrast, the endometrial microbiome shows reduced Lactobacillus abundance and greater microbial diversity. Studies involving infertile couples have demonstrated a positive correlation between the presence of Lactobacillus, particularly L. crispatus, and higher pregnancy and live birth rates. However, little is currently known about the interaction between the microbiome and the immunome in the female genital tract. Research in this area faces several challenges and requires standardized protocols to ensure comparability across studies.