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<p>This study aimed to evaluate the expression of endogenous irisin in serum and gingival tissue during the progression and repair of ligature-induced periodontitis in male rats, as well as its correlation with inflammatory markers. Forty-eight male Wistar rats were randomly assigned to experimental groups (<i>n</i> = 8/group): Control (no ligature); Ligature (7, 35, and 63 days); and Repair (28 and 56 days). Periodontitis was induced by placing a subgingival cotton ligature around the first molars. Repair was initiated by removing the ligature after 7 days. Serum and gingival tissue irisin levels were measured using enzyme-linked immunosorbent assay (ELISA), and a panel of inflammatory markers was assessed via multiplex analysis. No significant differences in serum irisin levels were found among the ligated groups or compared to the control group. However, gingival tissue irisin levels were significantly increased in the Ligature 7-day group compared to both the control and Ligature 63-day groups. In the Repair groups, no significant differences were observed compared to the Ligature 7-day group. A significant negative correlation was found between gingival irisin levels and tumor necrosis factor-alpha (TNF-α) during periodontitis progression, while significant positive correlations were observed with epidermal and vascular endothelial growth factors (EGF and VEGF, respectively) during periodontal repair. In conclusion, gingival irisin levels increase early during periodontitis progression, suggesting its role as a disease marker, and do not significantly decrease at the studied repair time points.</p>

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Expression of endogenous Irisin and associated markers during periodontitis progression and repair in male rats

  • 期刊论文

  • 发表日期：

    2025年8月22日

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  • Larysa Saboya Cavalotti Perdonsini,
  • João Victor Schoemberger Roth,
  • Priscila Alves Teixeira Ribas,
  • Henrique Kenji Takarada,
  • Mariana Ortelan Borges,
  • Flávia Braga Reitmeyer,
  • João César Zielak,
  • Joao Paulo Steffens

摘要

This study aimed to evaluate the expression of endogenous irisin in serum and gingival tissue during the progression and repair of ligature-induced periodontitis in male rats, as well as its correlation with inflammatory markers. Forty-eight male Wistar rats were randomly assigned to experimental groups (n = 8/group): Control (no ligature); Ligature (7, 35, and 63 days); and Repair (28 and 56 days). Periodontitis was induced by placing a subgingival cotton ligature around the first molars. Repair was initiated by removing the ligature after 7 days. Serum and gingival tissue irisin levels were measured using enzyme-linked immunosorbent assay (ELISA), and a panel of inflammatory markers was assessed via multiplex analysis. No significant differences in serum irisin levels were found among the ligated groups or compared to the control group. However, gingival tissue irisin levels were significantly increased in the Ligature 7-day group compared to both the control and Ligature 63-day groups. In the Repair groups, no significant differences were observed compared to the Ligature 7-day group. A significant negative correlation was found between gingival irisin levels and tumor necrosis factor-alpha (TNF-α) during periodontitis progression, while significant positive correlations were observed with epidermal and vascular endothelial growth factors (EGF and VEGF, respectively) during periodontal repair. In conclusion, gingival irisin levels increase early during periodontitis progression, suggesting its role as a disease marker, and do not significantly decrease at the studied repair time points.