Scholarlink

<p>Chemotherapy can cause adverse alterations in bone metabolism. Chemotherapy therefore can pose a risk for peri-implant bone healing. This study aimed to evaluate the effect of 5-Fluorouracil (5-FU) during the early and late peri-implant bone healing phase in a rat tibia model. Sixty males Wistar albinus rats received titanium implants into the tibia and they were divided into rats receiving 5-FU or controls treated with saline solution (SS). The chemotherapy was administered on day 15 at early peri-implant bone healing or day 30 at late peri-implant bone healing. Implant stability was evaluated by removal torque as the primary endpoint at 30 or 45 days after implantation. Microtomography, histomorphometry, histochemistry and immunohistochemistry data were evaluated as secondary parameters. Chemotherapy on day 15 at early peri-implant bone healing significantly decreased the removal torque in rats after 30 days of implantation compared to SS group (4.1 ± 0.3 vs. 11.2 ± 0.4; <i>p</i> &lt; 0.001) and rats who received 5-FU on day 30 (4.1 ± 0.3 vs. 10.7 ± 0.5; <i>p</i> &lt; 0.001). Confirming, microtomography and histomorphometry revealed less new bone formed in rats with chemotherapy on day 15 compared to SS and rats with 5-FU on day 30. Histochemistry showed a lower amount of mature collagen fibers when 5-FU was administered on day 15 but not on day 30. In immunohistochemistry, rats treated with 5-FU on day 15 showed lower osteocalcin immunolabeling. 5-FU can delay the early peri-implant bone healing phase when administered during the early period, however, the use of 5-FU does not have a significant effect on the late peri-implant bone healing.</p>

错误：搜索内容不能为空，请输入英文关键词
错误：关键词超出字数限制，请精简
高级检索

The effect of chemotherapy with 5-Fluorouracil on the early and late peri-implant bone healing phase: a study in rat tibia model

  • 期刊论文

  • 发表日期：

    2025年8月14日

查看全文
  • Márcio Luiz Ferro Alves,
  • Edilson Ervolino,
  • Rubens Spin-Neto,
  • Gabriel Mulinari-Santos,
  • Valdir Gouveia Garcia,
  • Liran Levin,
  • Letícia Helena Theodoro

摘要

Chemotherapy can cause adverse alterations in bone metabolism. Chemotherapy therefore can pose a risk for peri-implant bone healing. This study aimed to evaluate the effect of 5-Fluorouracil (5-FU) during the early and late peri-implant bone healing phase in a rat tibia model. Sixty males Wistar albinus rats received titanium implants into the tibia and they were divided into rats receiving 5-FU or controls treated with saline solution (SS). The chemotherapy was administered on day 15 at early peri-implant bone healing or day 30 at late peri-implant bone healing. Implant stability was evaluated by removal torque as the primary endpoint at 30 or 45 days after implantation. Microtomography, histomorphometry, histochemistry and immunohistochemistry data were evaluated as secondary parameters. Chemotherapy on day 15 at early peri-implant bone healing significantly decreased the removal torque in rats after 30 days of implantation compared to SS group (4.1 ± 0.3 vs. 11.2 ± 0.4; p < 0.001) and rats who received 5-FU on day 30 (4.1 ± 0.3 vs. 10.7 ± 0.5; p < 0.001). Confirming, microtomography and histomorphometry revealed less new bone formed in rats with chemotherapy on day 15 compared to SS and rats with 5-FU on day 30. Histochemistry showed a lower amount of mature collagen fibers when 5-FU was administered on day 15 but not on day 30. In immunohistochemistry, rats treated with 5-FU on day 15 showed lower osteocalcin immunolabeling. 5-FU can delay the early peri-implant bone healing phase when administered during the early period, however, the use of 5-FU does not have a significant effect on the late peri-implant bone healing.