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<p>The increasing incidence of optic neuropathies like glaucoma, ischemic, and hereditary optic conditions poses an escalating challenge to timely diagnosis and early treatment. Conventional ophthalmic imaging and functional testing, handicapped by their static nature, are unable to capture the brain’s adaptive neuroplastic reactions to progressive vision loss. To address this, we put forth NeuroScopeXR, a cognitive-mimetic paradigm using Virtual and Augmented Reality (VR/AR) to model and forecast compensatory neural responses in the vision-cognitive system. NeuroScopeXR combines real-time retinal imaging, cortical activity maps through fMRI, and interactive visual stimuli to generate neuro-adaptive profiles tailored to the individual. It simulates mechanisms like gaze recalibration, peripheral field optimization, and attentional remapping—allowing for prediction of vision loss and measurement of neuroplastic potential. A special cognitive engine interprets user response in immersive environments to predict the path of degeneration as well as the adaptive strategies adopted by the brain. Compared with traditional methods, NeuroScopeXR enhances early detection accuracy by 30–35%, predicts visual field decline with 25–40% more accuracy, and detects occult degenerative changes with up to 30% greater sensitivity. By moving diagnostics from static ocular markers to dynamic visuo-cognitive forecasting, NeuroScopeXR facilitates proactive, personalized, and brain-focused neuro-ophthalmic care.</p>

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NeuroScopeXR: a cognitive-mimetic VR/AR framework for predictive forecasting of optic neuropathies via neuroplasticity simulation

  • 期刊论文

  • 发表日期：

    2025年12月1日

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  • Parimala Veluvali,
  • R Meenakshi,
  • G. M. Jayaseelan

摘要

The increasing incidence of optic neuropathies like glaucoma, ischemic, and hereditary optic conditions poses an escalating challenge to timely diagnosis and early treatment. Conventional ophthalmic imaging and functional testing, handicapped by their static nature, are unable to capture the brain’s adaptive neuroplastic reactions to progressive vision loss. To address this, we put forth NeuroScopeXR, a cognitive-mimetic paradigm using Virtual and Augmented Reality (VR/AR) to model and forecast compensatory neural responses in the vision-cognitive system. NeuroScopeXR combines real-time retinal imaging, cortical activity maps through fMRI, and interactive visual stimuli to generate neuro-adaptive profiles tailored to the individual. It simulates mechanisms like gaze recalibration, peripheral field optimization, and attentional remapping—allowing for prediction of vision loss and measurement of neuroplastic potential. A special cognitive engine interprets user response in immersive environments to predict the path of degeneration as well as the adaptive strategies adopted by the brain. Compared with traditional methods, NeuroScopeXR enhances early detection accuracy by 30–35%, predicts visual field decline with 25–40% more accuracy, and detects occult degenerative changes with up to 30% greater sensitivity. By moving diagnostics from static ocular markers to dynamic visuo-cognitive forecasting, NeuroScopeXR facilitates proactive, personalized, and brain-focused neuro-ophthalmic care.