LP norm regularized deep CNN classifier based on biwolf optimization for mitosis detection in histopathology images

Mitosis detection, a crucial biomedical process, faces challenges like cell morphology variability, poor contrast, overcrowding, and limited annotated dataset availability. This research presents a novel method for mitosis detection in histopathological images highlighting two important contributions using a Bi-wolf optimization-based LP norm regularized deep Convolutional neural network (CNN) model. This hybrid optimization protocol is the key to the precise calibration of model parameters and effective training, which translates into optimal classifier performance. The results reveal that this model achieves high accuracy, sensitivity, and specificity values of 96.69%, 91.89%, and 97.74% respectively.