We study the large-time asymptotics of global solutions to the semilinear heat equation in \({\mathbb {R}}^n\) ( \(n\ge 3\) ) with critical Sobolev exponent \(\begin{aligned} {\left\{ \begin{array}{ll} u_t=\Delta u+|u|^{\frac{4}{n-2}} u ~& \hbox { in }~ {{{\mathbb {R}}}}^n \times (0,\infty ),\\ u(\cdot ,0)=u_0~& \hbox { in }~ {{{\mathbb {R}}}}^n. \end{array}\right. } \end{aligned}\) For \(n=6\) , we construct global and positive solutions for a class of initial value \(u_0(x)\sim |x|^{-\gamma }\) as \(|x|\rightarrow \infty \) with \(\gamma >2\) such that the asymptotics of \(\Vert u\Vert _{L^\infty ({\mathbb {R}}^6)}\) depends on \(\gamma \) in a precise manner, motivating by a program proposed by Fila and King [11]. Some remarks on the lower dimensional cases are given.