In this work, we study the two following minimization problems for \(r \in \mathbb {N}^{*}\) , \(\begin{aligned} \begin{array}{ccc} S_{0,r}(\varphi )=\displaystyle \inf _{u\in H_{0}^{r}(\Omega ),\,\Vert u+\varphi \Vert _{L^{2^{*r}}}=1}\Vert u\Vert _{r}^{2}&\text { and }\,\,&S_{\theta ,r}(\varphi )=\displaystyle \inf _{u\in H_{\theta }^{r}(\Omega ),\,\Vert u+\varphi \Vert _{L^{2^{*r}}}=1}\Vert u\Vert _{r}^{2}, \end{array} \end{aligned}\) where \(\Omega \subset \mathbb {R}^{N}, \) \(N > 2r\) , is a smooth bounded domain, \(2^{*r}=\frac{2N}{N-2 r}\) , \(\varphi \in L^{2^{*r}} (\Omega ) \cap C(\Omega )\) and the norm \(\Vert . \Vert _{r}=\displaystyle { \int _{\Omega } |(-\Delta )^{\alpha }.|^{2}dx}\) where \( \alpha =\frac{r}{2} \) if r is even and \(\Vert . \Vert _{r}=\displaystyle { \int _{\Omega } |\nabla (-\Delta )^{\alpha }. |^{2}dx }\) where \(\alpha = \frac{r-1}{2}\) if r is odd. Firstly, we prove that, when \(\varphi \not \equiv 0, \) the infimum in \(S_{0,r}(\varphi )\) and \(S_{\theta ,r}(\varphi )\) are achieved. Secondly, we show that \( S_{\theta ,r}(\varphi )< S_{0,r}(\varphi ) \) for a large class of \(\varphi \) .