The aim of this paper is the study of first-order stationary systems of PDEs of the form \(\sum _k A_k\partial _k U + KU=0\) with \(K\ngtr 0\) on \(\Omega = {\mathbb {R}}^d\) and \(\Omega \subset {\mathbb {R}}^d\) bounded. We prove that the classical assumption \(K>0\) is not necessary for the well-posedness of the system and is violated in the particular case of the first-order Poisson problem. In the case \(\Omega = {\mathbb {R}}^d,\) we use Fourier analysis for the existence and uniqueness of solutions. For \(\Omega \subset {\mathbb {R}}^d\) bounded, we use a complex analog of the Banach–Nečas–Babuška theorem to obtain the existence and uniqueness of a solution in a setting that encompasses both Friedrichs’ systems and the first order reduction of the Poisson problem. The techniques used to prove the classical inf-sup conditions are inspired by harmonic analysis arguments that are consistent with the case \(\Omega ={\mathbb {R}}^d.\) In order to illustrate our approach, we study in detail the reduction of the Poisson equation to a first-order system.