Scholarlink

Objective <p>To systematically review observational evidence on the association between CRD and urolithiasis risk.</p> Methods <p>This review was registered in PROSPERO (CRD420251127344) and conducted per PRISMA 2020 guidelines. PubMed and EBSCOhost were searched to August 2025 using Medical Subject Headings and free-text terms for circadian rhythm, sleep, shift work, and kidney stones. Eligible studies included observational designs in adults, assessing CRD exposure and reporting prevalence or incidence of kidney stones. Two reviewers independently screened records via Rayyan.AI, extracted data, and appraised quality using the Newcastle–Ottawa Scale (NOS).</p> Results <p>Of 210 records, three studies met inclusion: two cross-sectional (n = 4603; n = 9797) and one prospective cohort (n = 154,990 across two U.S. nurse cohorts). CRD definitions included circadian syndrome, poor sleep quality, and current rotating night-shift work. Across studies, CRD was associated with increased kidney stone risk (OR 1.178–1.42; HR 1.13), with stronger associations in younger individuals, women, and certain racial/ethnic subgroups. NOS scores were uniformly high, but GRADE certainty ranged from low to moderate.</p> Conclusion <p>CRD appears to modestly but consistently increase urolithiasis risk, potentially through melatonin suppression, altered urinary calcium/oxalate handling, metabolic disturbances, and dehydration in night-shift workers. Large, diverse, prospective studies using objective CRD measures are needed to confirm causality and guide prevention strategies integrating circadian health.</p>

错误：搜索内容不能为空，请输入英文关键词
错误：关键词超出字数限制，请精简
高级检索

Circadian Rhythm Disruption and Risk of Urolithiasis: A Systematic Review

  • 期刊论文

  • 发表日期：

    2026年8月4日

查看全文
  • Nicholas Andrian Singgih,
  • Ferry Safriadi

摘要

Objective

To systematically review observational evidence on the association between CRD and urolithiasis risk.

Methods

This review was registered in PROSPERO (CRD420251127344) and conducted per PRISMA 2020 guidelines. PubMed and EBSCOhost were searched to August 2025 using Medical Subject Headings and free-text terms for circadian rhythm, sleep, shift work, and kidney stones. Eligible studies included observational designs in adults, assessing CRD exposure and reporting prevalence or incidence of kidney stones. Two reviewers independently screened records via Rayyan.AI, extracted data, and appraised quality using the Newcastle–Ottawa Scale (NOS).

Results

Of 210 records, three studies met inclusion: two cross-sectional (n = 4603; n = 9797) and one prospective cohort (n = 154,990 across two U.S. nurse cohorts). CRD definitions included circadian syndrome, poor sleep quality, and current rotating night-shift work. Across studies, CRD was associated with increased kidney stone risk (OR 1.178–1.42; HR 1.13), with stronger associations in younger individuals, women, and certain racial/ethnic subgroups. NOS scores were uniformly high, but GRADE certainty ranged from low to moderate.

Conclusion

CRD appears to modestly but consistently increase urolithiasis risk, potentially through melatonin suppression, altered urinary calcium/oxalate handling, metabolic disturbances, and dehydration in night-shift workers. Large, diverse, prospective studies using objective CRD measures are needed to confirm causality and guide prevention strategies integrating circadian health.