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<p>A spray drying technique was applied to prepare granulated BT/β-TCP (bariumtitanate/ β-tricalcium phosphate) powders with various compositions, and then the granulated BT/β-TCP/collagen scaffolds were prepared using the freeze-drying method. Our experimental results showed that the values of compressive modulus for the 22.5, 45.0, and 67.5wt% β-TCP-contained scaffolds were 2.29±0.11, 3.20±0.25, and 3.39±0.39&#xa0;MPa, respectively, which are much higher than that of the pure collagen scaffold (compressive modulus of 1.58 ± 0.23&#xa0;MPa). In addition, the 22.5wt% β-TCP-contained scaffold only degrades 9.5% after 28 days, compared to 100% degradation of the pure collagen scaffold. Finally, this study explored the relationships between porosity, mechanical properties, and biodegradation behavior of granulated BT/β-TCP/collagen scaffolds.</p>

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Granulated barium titanate/ ꞵ-tricalcium phosphate/collagen scaffolds: preparation and characterization for bone tissue engineering

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2025年9月16日

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  • Dwi Fortuna Anjusa Putra,
  • Ting-Wei Wu,
  • Shao-Ju Shih

摘要

A spray drying technique was applied to prepare granulated BT/β-TCP (bariumtitanate/ β-tricalcium phosphate) powders with various compositions, and then the granulated BT/β-TCP/collagen scaffolds were prepared using the freeze-drying method. Our experimental results showed that the values of compressive modulus for the 22.5, 45.0, and 67.5wt% β-TCP-contained scaffolds were 2.29±0.11, 3.20±0.25, and 3.39±0.39 MPa, respectively, which are much higher than that of the pure collagen scaffold (compressive modulus of 1.58 ± 0.23 MPa). In addition, the 22.5wt% β-TCP-contained scaffold only degrades 9.5% after 28 days, compared to 100% degradation of the pure collagen scaffold. Finally, this study explored the relationships between porosity, mechanical properties, and biodegradation behavior of granulated BT/β-TCP/collagen scaffolds.