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<p>A bioresorbable film composed of 10 wt% β-tricalcium phosphate (BTCP) integrated into a 10 wt% PVA matrix was successfully fabricated via solution casting method. Structural analysis using FESEM revealed agglomerated BTCP particles within the PVA matrix, while EDX quantified the elemental composition as Carbon (55.34%), Oxygen (32.82%), Calcium (7.20%), Sulfur (3.84%), Phosphorus (0.50%), and Sodium (0.30%). XRD confirmed a monoclinic gypsum-like structure with an average crystallite size of 110.83&#xa0;nm. Thermal analysis showed a peak melting temperature of 165.9&#xa0;°C and energy absorption of 164.4&#xa0;J/g, with thermal stability up to 160 ± 5&#xa0;°C and a total mass loss of 68.95% by 550&#xa0;°C. Mechanical testing indicated a tensile strength of 3.42&#xa0;MPa, an elastic modulus of 2.5&#xa0;MPa, and a fracture strain of 16.4%, aligning with requirements for soft-load biomedical scaffolds. In-vitro cytotoxicity using L929 cells demonstrated high viability of 90% at 5 µL and moderate cytotoxicity (64%) at 100 µL, indicating concentration-dependent biocompatibility. These results support the film’s suitability for biomedical applications such as bone grafts, scaffold coatings, and biodegradable membranes.</p>

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Structural, mechanical, thermal, and in-vitro characterization of tricalcium phosphate loaded Polyvinylalcohol film

  • 期刊论文

  • 发表日期：

    2025年8月25日

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  • C. Balaji Ayyanar,
  • S. K. Pradeep Mohan,
  • Jack J. Kenned

摘要

A bioresorbable film composed of 10 wt% β-tricalcium phosphate (BTCP) integrated into a 10 wt% PVA matrix was successfully fabricated via solution casting method. Structural analysis using FESEM revealed agglomerated BTCP particles within the PVA matrix, while EDX quantified the elemental composition as Carbon (55.34%), Oxygen (32.82%), Calcium (7.20%), Sulfur (3.84%), Phosphorus (0.50%), and Sodium (0.30%). XRD confirmed a monoclinic gypsum-like structure with an average crystallite size of 110.83 nm. Thermal analysis showed a peak melting temperature of 165.9 °C and energy absorption of 164.4 J/g, with thermal stability up to 160 ± 5 °C and a total mass loss of 68.95% by 550 °C. Mechanical testing indicated a tensile strength of 3.42 MPa, an elastic modulus of 2.5 MPa, and a fracture strain of 16.4%, aligning with requirements for soft-load biomedical scaffolds. In-vitro cytotoxicity using L929 cells demonstrated high viability of 90% at 5 µL and moderate cytotoxicity (64%) at 100 µL, indicating concentration-dependent biocompatibility. These results support the film’s suitability for biomedical applications such as bone grafts, scaffold coatings, and biodegradable membranes.