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<p>The synthesis of ZnO-NPs through bio-reduction, particularly from plant extracts, has attracted the attention of scientists in recent years. Despite the enhanced popularity use of <i>Xylopia aethiopica</i> seeds as an aromatic spice, there has not been a study on the evaluation for phytosynthesis of ZnO-NPs until today. Here, for manufacturing of ZnO-NPs, bio-reduction of an aqueous zinc acetate dihydrate precursor solution by <i>X. aethiopica</i> aqueous seed extract including various phytochemical constituents is presented. The strong peak of ZnO-NPs is observed around 363&#xa0;nm in the UV region below 400&#xa0;nm. SEM images displayed ZnO-NPs to be clustered in semi-spherical shapes with a size range from 15.38 to 6.75&#xa0;nm. XRD pattern matched that of JCPDS card 98-002-9272 confirming the pure hexagonal nanocrystals structure of ZnO-NPs. The indirect band gap of spherical-shaped ZnO-NPs with crystallite size 17.5&#xa0;nm size was 3.04&#xa0;eV. EDX demonstrates that ZnO-NPs primarily consist of zinc (53.76%) and oxygen (46.24%) by the atomic percent ratios almost 1:1. FTIR spectrum shows the analysis functional group of bioactive components performing the bio-reduction of bulk precursor to ZnO-NPs, and the absorption band at 421&#xa0;cm<sup>− 1</sup> confirms the formation of Zn-O. In vitro studies exhibited excellent anti-quorum sensing activity (72.18–92.84%), and anti-biofilm activity (2.9–75.8%) of biogenic ZnO-NPs in a dose-dependent manner, thus suggesting that ZnO-NPs can be used in the prevention of infectious diseases originated from bacteria in many industrial application such as veterinary, medicine, and food preservation.</p>

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Inhibition potential on virulence factors of bacterial pathogens by Uda-mediated synthesized ZnO-NPs: in vitro analyses

  • 期刊论文

  • 发表日期：

    2025年8月6日

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  • Melis Sumengen Ozdenefe,
  • Deniz Kadir Takcı,
  • Hatice Calban,
  • Merve Alkan,
  • Hatice Aysun Mercimek Takcı

摘要

The synthesis of ZnO-NPs through bio-reduction, particularly from plant extracts, has attracted the attention of scientists in recent years. Despite the enhanced popularity use of Xylopia aethiopica seeds as an aromatic spice, there has not been a study on the evaluation for phytosynthesis of ZnO-NPs until today. Here, for manufacturing of ZnO-NPs, bio-reduction of an aqueous zinc acetate dihydrate precursor solution by X. aethiopica aqueous seed extract including various phytochemical constituents is presented. The strong peak of ZnO-NPs is observed around 363 nm in the UV region below 400 nm. SEM images displayed ZnO-NPs to be clustered in semi-spherical shapes with a size range from 15.38 to 6.75 nm. XRD pattern matched that of JCPDS card 98-002-9272 confirming the pure hexagonal nanocrystals structure of ZnO-NPs. The indirect band gap of spherical-shaped ZnO-NPs with crystallite size 17.5 nm size was 3.04 eV. EDX demonstrates that ZnO-NPs primarily consist of zinc (53.76%) and oxygen (46.24%) by the atomic percent ratios almost 1:1. FTIR spectrum shows the analysis functional group of bioactive components performing the bio-reduction of bulk precursor to ZnO-NPs, and the absorption band at 421 cm− 1 confirms the formation of Zn-O. In vitro studies exhibited excellent anti-quorum sensing activity (72.18–92.84%), and anti-biofilm activity (2.9–75.8%) of biogenic ZnO-NPs in a dose-dependent manner, thus suggesting that ZnO-NPs can be used in the prevention of infectious diseases originated from bacteria in many industrial application such as veterinary, medicine, and food preservation.