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<p>This work presents a comprehensive investigation into the sustainable synthesis and extensive characterization of zirconium oxide (ZrO<sub>2</sub>) nanopowder. The study examines the anticancer properties of the synthesized nanoparticles as well as their electrochemical behavior using potentiodynamic polarization (PDP) and electrochemical impedance spectroscopy (EIS). The fascinating attributes of ZrO<sub>2</sub> nanoparticles were elucidated through detailed analyses, including powder X-ray diffraction (PXRD), field emission scanning electron microscopy (FESEM), Fourier-transform infrared spectroscopy (FT-IR), and UV–visible spectroscopy (UV–vis). PXRD analysis confirmed a monoclinic crystal structure with crystallite size within the range of 30–40&#xa0;nm. FESEM reveals irregular shapes and agglomeration of particles, UV–vis showed absorption peak at 347&#xa0;nm with an energy gap (Eg) of 3.16&#xa0;eV and FT-IR studies reveals metal–oxygen bonds at 594&#xa0;cm⁻<sup>1</sup>. Additionally, electrochemical studies using PDP and EIS investigated the inhibition efficiency of nanoparticles dispersed in an acidic medium (1&#xa0;M HCl). Anti-oncogenic studies conducted via MTT assay illustrated the efficacy of ZrO<sub>2</sub> NPs against the MDA-MB-231 cell line with an IC50 value of 22.56&#xa0;µg/mL. Our findings underscore the versatile potential applications of ZrO<sub>2</sub> nanoparticles and provide significant new insights into their optical, structural, electrochemical, and anticancer properties.</p>

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Exploring the multifaceted potential of ZrO2 nanoparticles: sustainable synthesis, anticancer properties, and electrochemical insight

  • 期刊论文

  • 发表日期：

    2025年3月28日

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  • N. P. Bhagya,
  • Srilatha Rao,
  • G. K. Prashanth,
  • A. S. Sowmyashree,
  • Smitha Shree S,
  • H. S. Lalithamba,
  • S. R. Yashodha,
  • Manoj Gadewar

摘要

This work presents a comprehensive investigation into the sustainable synthesis and extensive characterization of zirconium oxide (ZrO2) nanopowder. The study examines the anticancer properties of the synthesized nanoparticles as well as their electrochemical behavior using potentiodynamic polarization (PDP) and electrochemical impedance spectroscopy (EIS). The fascinating attributes of ZrO2 nanoparticles were elucidated through detailed analyses, including powder X-ray diffraction (PXRD), field emission scanning electron microscopy (FESEM), Fourier-transform infrared spectroscopy (FT-IR), and UV–visible spectroscopy (UV–vis). PXRD analysis confirmed a monoclinic crystal structure with crystallite size within the range of 30–40 nm. FESEM reveals irregular shapes and agglomeration of particles, UV–vis showed absorption peak at 347 nm with an energy gap (Eg) of 3.16 eV and FT-IR studies reveals metal–oxygen bonds at 594 cm⁻1. Additionally, electrochemical studies using PDP and EIS investigated the inhibition efficiency of nanoparticles dispersed in an acidic medium (1 M HCl). Anti-oncogenic studies conducted via MTT assay illustrated the efficacy of ZrO2 NPs against the MDA-MB-231 cell line with an IC50 value of 22.56 µg/mL. Our findings underscore the versatile potential applications of ZrO2 nanoparticles and provide significant new insights into their optical, structural, electrochemical, and anticancer properties.