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<p>The exceptional magnetic properties of magnetite and Fe<sub>3</sub>O<sub>4</sub> nanoparticles make them the most intensively reported inorganic nanomaterials in cancer research. Here, Fe<sub>3</sub>O<sub>4</sub> nanoparticles were prepared by the chemical co-precipitation method and loaded with dual chemotherapeutic drugs, methotrexate (MTX) and SN38 (Fe<sub>3</sub>O<sub>4</sub>-SN38-MTX), to achieve tumor-targeting potency and elevate the dual therapeutic antitumor efficacy towards the breast cancer cells. The synthesized Fe<sub>3</sub>O<sub>4</sub> nanoparticles exhibit excellent magnetic hyperthermic performance (MHT) because of their superparamagnetic behavior and attain saturation magnetization at 66.37 emu/g. Moreover, the double drug conjugation of Fe<sub>3</sub>O<sub>4</sub> nanoparticles exhibits enhanced MHT efficiency due to its dual-chemotherapy performance. The successful preparation of Fe<sub>3</sub>O<sub>4</sub>-SN38-MTX nanoparticles was confirmed by XRD, FTIR, and UV-visible studies. Additionally, the magnetic property was investigated using SQUID, and their Fe<sub>3</sub>O<sub>4</sub>-SN38-MTX nanoparticles’ cytotoxic performance was evaluated by CCK-8 analysis of L929 and 4T1 cells. As a result, the prepared Fe<sub>3</sub>O<sub>4</sub>-SN38-MTX nanoparticles exhibit 64% tumor cell death via combinational therapy (MHT/CT) than single therapy.</p>

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Integrating hyperthermia and chemotherapy: an intriguing approach based on Fe3O4 nanoparticles grafted with SN38 and MTX dual drugs for cancer theranostics

  • 期刊论文

  • 发表日期：

    2025年3月19日

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  • Kayalvizhi Samuvel Muthiah,
  • Lenin Subramanian,
  • Ya-Wen Hsiao,
  • Yu-Chien Lin,
  • Yuan-Yun Tseng,
  • Ren-Jei Chung

摘要

The exceptional magnetic properties of magnetite and Fe3O4 nanoparticles make them the most intensively reported inorganic nanomaterials in cancer research. Here, Fe3O4 nanoparticles were prepared by the chemical co-precipitation method and loaded with dual chemotherapeutic drugs, methotrexate (MTX) and SN38 (Fe3O4-SN38-MTX), to achieve tumor-targeting potency and elevate the dual therapeutic antitumor efficacy towards the breast cancer cells. The synthesized Fe3O4 nanoparticles exhibit excellent magnetic hyperthermic performance (MHT) because of their superparamagnetic behavior and attain saturation magnetization at 66.37 emu/g. Moreover, the double drug conjugation of Fe3O4 nanoparticles exhibits enhanced MHT efficiency due to its dual-chemotherapy performance. The successful preparation of Fe3O4-SN38-MTX nanoparticles was confirmed by XRD, FTIR, and UV-visible studies. Additionally, the magnetic property was investigated using SQUID, and their Fe3O4-SN38-MTX nanoparticles’ cytotoxic performance was evaluated by CCK-8 analysis of L929 and 4T1 cells. As a result, the prepared Fe3O4-SN38-MTX nanoparticles exhibit 64% tumor cell death via combinational therapy (MHT/CT) than single therapy.