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<p>The study investigates the organochlorinated pesticides (OPCs) content in eight medicinal plant species (<i>Achillea millefolium, Artemisia absinthum</i><i>, </i><i>Hypericum perforatum</i><i>, </i><i>Tilia sp., Matricaria chamomilla</i><i>, </i><i>Taraxacum officinale, Calendula officinalis, Crataegus monogyna</i>), purchased from pharmacies, as well as in infusions prepared from these plants. A total number of 24 samples were analyzed by gas chromatography—electron capture detector (GC-ECD). The transfer rate of OPCs from dried herbs to infusions, as well as the health risk of OPCs residues in infusions (estimated daily intake (EDI) and Hazard Index (HI) were calculated. All medicinal plants (MPs) contained pesticides in different concentrations. For the compounds Heptachlor, p,p' DDT, p,p' DDD, Aldrin, Dieldrin, concentrations well above the maximum residue limits (MRLs) were obtained. The transfer rate of organochlorine pesticides from dried plant to infusion ranged from 3.95% for Heptachlor (<i>Artemisia absinthium</i>) to 57.71% for Dieldrin (<i>Achillea millefolium</i>). The correlation between the OCPs content in the MPs and their infusion are statistically analyzed using the t-test for independence in high dimension, based on the correlation distance. Significant result was found for all OCP detected in the two media, with the content in the MPs significantly correlated with the content in the infusion. The EDI of the detected pesticides was lower than the Acceptable Daily Intake (ADI), and the Hazard Index values were less than 1 (HI &lt; 1) in all infusions. Also, the cumulative hazard index (CHI), showed values less than 1 (CHI &lt; 1) for all types of tea. These results indicate that residues of OCPs in the analysed infusions pose minimal risk to human health. However, taking into account the large transfer variations obtained, the results of the study recommend the development of control protocols for herbal infusions intended for human therapy that include the measurement of OCPs concentrations. </p>

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Determination of Organochlorine Pesticides' Content in Dried Medicinal Plants and Their Infusions—Risk to Human Health

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2025年6月1日

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  • Mihaela Mirela Bratu,
  • Semaghiul Birghila,
  • Corina Birghila,
  • Diana Andreea Danilov,
  • Valentina Coatu,
  • Elena Ristea,
  • Nicoleta Alexandra Damir

摘要

The study investigates the organochlorinated pesticides (OPCs) content in eight medicinal plant species (Achillea millefolium, Artemisia absinthum, Hypericum perforatum, Tilia sp., Matricaria chamomilla, Taraxacum officinale, Calendula officinalis, Crataegus monogyna), purchased from pharmacies, as well as in infusions prepared from these plants. A total number of 24 samples were analyzed by gas chromatography—electron capture detector (GC-ECD). The transfer rate of OPCs from dried herbs to infusions, as well as the health risk of OPCs residues in infusions (estimated daily intake (EDI) and Hazard Index (HI) were calculated. All medicinal plants (MPs) contained pesticides in different concentrations. For the compounds Heptachlor, p,p' DDT, p,p' DDD, Aldrin, Dieldrin, concentrations well above the maximum residue limits (MRLs) were obtained. The transfer rate of organochlorine pesticides from dried plant to infusion ranged from 3.95% for Heptachlor (Artemisia absinthium) to 57.71% for Dieldrin (Achillea millefolium). The correlation between the OCPs content in the MPs and their infusion are statistically analyzed using the t-test for independence in high dimension, based on the correlation distance. Significant result was found for all OCP detected in the two media, with the content in the MPs significantly correlated with the content in the infusion. The EDI of the detected pesticides was lower than the Acceptable Daily Intake (ADI), and the Hazard Index values were less than 1 (HI < 1) in all infusions. Also, the cumulative hazard index (CHI), showed values less than 1 (CHI < 1) for all types of tea. These results indicate that residues of OCPs in the analysed infusions pose minimal risk to human health. However, taking into account the large transfer variations obtained, the results of the study recommend the development of control protocols for herbal infusions intended for human therapy that include the measurement of OCPs concentrations.