Scholarlink

<p>Pharmaceutical pollution refers to the introduction of metabolites of drugs into the environment because of their use by humans and animals, leading to chemical and biological contamination. Recently, pharmaceutically active substances have been detected in many aquatic environments. In this study, the occurrence of fluoxetine and serotonin hormone was examined in the water column of Istanbul Strait, Türkiye, and environmental risk assessment was conducted in June, August, and October of 2022. Liquid–liquid extraction (LLE) and solid phase extraction (SPE) methods were employed for the extraction of analytes from water samples, followed by derivatization and analysis via the&#xa0;gas chromatography–mass spectrometry (GC–MS) technique. Pharmaceutical and hormone levels were detected under the intermediate layer and bottom layer, but the concentrations of the target compounds at the&#xa0;upper layer were &lt; method detection limit (MDL). In this study, fluoxetine concentration were found between 4.05–69.8&#xa0;ng/L and serotonin concentration were found between 1.42 and 32.84&#xa0;ng/L. Based on the environmental risk assessment results, fluoxetine poses a moderate risk for <i>daphnia</i> but a low risk for algae and fish. The risk associated with serotonin was accepted as negligible in the assessment. This study represents the first investigation of pharmaceutical pollution caused by deep-sea discharge in the Istanbul Strait&#xa0;and the first study to examine the presence of&#xa0;serotonin hormone in the marine environment globally.</p>

错误：搜索内容不能为空，请输入英文关键词
错误：关键词超出字数限制，请精简
高级检索

Presence and Environmental Risk Assessment of Fluoxetine and Serotonin Hormone in the Istanbul Strait, Türkiye

  • 期刊论文

  • 发表日期：

    2025年2月25日

查看全文
  • Güldehan Deryal,
  • Nagihan Ersoy Korkmaz,
  • Abdullah Aksu,
  • Timuçin Kapudan,
  • Cem Gazioğlu,
  • Nuray Çağlar Balkıs

摘要

Pharmaceutical pollution refers to the introduction of metabolites of drugs into the environment because of their use by humans and animals, leading to chemical and biological contamination. Recently, pharmaceutically active substances have been detected in many aquatic environments. In this study, the occurrence of fluoxetine and serotonin hormone was examined in the water column of Istanbul Strait, Türkiye, and environmental risk assessment was conducted in June, August, and October of 2022. Liquid–liquid extraction (LLE) and solid phase extraction (SPE) methods were employed for the extraction of analytes from water samples, followed by derivatization and analysis via the gas chromatography–mass spectrometry (GC–MS) technique. Pharmaceutical and hormone levels were detected under the intermediate layer and bottom layer, but the concentrations of the target compounds at the upper layer were < method detection limit (MDL). In this study, fluoxetine concentration were found between 4.05–69.8 ng/L and serotonin concentration were found between 1.42 and 32.84 ng/L. Based on the environmental risk assessment results, fluoxetine poses a moderate risk for daphnia but a low risk for algae and fish. The risk associated with serotonin was accepted as negligible in the assessment. This study represents the first investigation of pharmaceutical pollution caused by deep-sea discharge in the Istanbul Strait and the first study to examine the presence of serotonin hormone in the marine environment globally.