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<p>Amantadine is a well-known antiviral medication for its effectiveness against the influenza A virus. Depression, cocaine addiction, and Parkinson’s disease are just a few of the conditions that may benefit from its use. In order to stop the virus from infecting host cells, amantadine’s antiviral effect requires that ion channel proteins in the viral envelope be targeted. Although its precise mechanism of action in Parkinson’s disease treatment is uncertain, it is thought to involve either modulating neuronal transmission at the neuromuscular junction or enhancing dopamine production and release. Rapid and precise amantadine detection is crucial for many applications. Surface-enhanced Raman spectroscopy (SERS) is a rapid and precise method for detecting chemicals at low levels. In this study, SERS biosensors were developed for the detection of amantadine by employing filter paper substrates covered with silver nanoparticles (AgNPs). The chemical reduction process used to produce the AgNPs was analyzed using a number of different analytical techniques. Using the coated substrates as active sites, molecular vibrations of amantadine could be observed. By accurately recognizing low concentrations of amantadine, SERS biosensors demonstrated a detection limit of 10<sup>–10</sup>&#xa0;M. The RSD was calculated to be 4.13% after repeated evaluations. At a concentration of 10<sup>–6</sup>&#xa0;M amantadine, experimental and computational studies yielded an enhancement factor of 3.293 × 10<sup>5</sup> and 9.76 × 10<sup>5</sup>, respectively. These findings support the substrates’ usefulness for recognizing low amantadine concentrations, which makes them suitable for drug monitoring.</p>

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Flexible and plasmonic substrates based on filter papers for the detection of amantadine

  • 期刊论文

  • 发表日期：

    2025年10月23日

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  • Rawaa M. Mohammed,
  • Mohammed H. Abbas,
  • Saeideh Mehmandoust,
  • Noor Hayder,
  • Vahid Eskandari,
  • Amin Hadi

摘要

Amantadine is a well-known antiviral medication for its effectiveness against the influenza A virus. Depression, cocaine addiction, and Parkinson’s disease are just a few of the conditions that may benefit from its use. In order to stop the virus from infecting host cells, amantadine’s antiviral effect requires that ion channel proteins in the viral envelope be targeted. Although its precise mechanism of action in Parkinson’s disease treatment is uncertain, it is thought to involve either modulating neuronal transmission at the neuromuscular junction or enhancing dopamine production and release. Rapid and precise amantadine detection is crucial for many applications. Surface-enhanced Raman spectroscopy (SERS) is a rapid and precise method for detecting chemicals at low levels. In this study, SERS biosensors were developed for the detection of amantadine by employing filter paper substrates covered with silver nanoparticles (AgNPs). The chemical reduction process used to produce the AgNPs was analyzed using a number of different analytical techniques. Using the coated substrates as active sites, molecular vibrations of amantadine could be observed. By accurately recognizing low concentrations of amantadine, SERS biosensors demonstrated a detection limit of 10–10 M. The RSD was calculated to be 4.13% after repeated evaluations. At a concentration of 10–6 M amantadine, experimental and computational studies yielded an enhancement factor of 3.293 × 105 and 9.76 × 105, respectively. These findings support the substrates’ usefulness for recognizing low amantadine concentrations, which makes them suitable for drug monitoring.