<p>Despite the role of hope in disease recovery, it is not considered a component of the physician–patient relationship in modern medical literature. However, Persian medicine (PM) believes that hope should always be inspired. We explored this issue by comparing the PM opinions with those of modern medical ethics (MME). Using a descriptive-analytical method and relying on historical library evidence, we investigated the ideas of two famous Persian thinkers. After classifying the data on the areas related to the physician–patient relationship in PM and MME, the role of “hope-giving” was compared with four principles of biomedical ethics. We found that the physician’s obligations to the patient were similar in the two perspectives. The only difference was the emphasis of the sages on “always giving hope to the patient,” which did not seem to follow the principle of truth-telling in MME. An in-depth analysis of the concept in both perspectives resolved this disagreement by indicating that the PM principle of “always giving hope to the patient” was in line with the four principles of MME. It is suggested that hope-giving skills should be included in the physician training system to improve the physician–patient relationship and achieve better outcomes.</p>