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Purpose <p>To evaluate whether adjunctive photobiomodulation (PBM) improves the predictability of digitally prescribed transverse expansion during clear aligner therapy.</p> Methods <p>In this single-center pilot randomized clinical trial, 30 participants undergoing clear aligner therapy were randomized to aligners alone (control) or aligners with adjunctive photobiomodulation (test). Identical digitally prescribed transverse expansion was planned for both groups. Cone-beam computed tomography (CBCT) and digital models were obtained at baseline (T0) and after completion of a 14-aligner protocol (T1). Outcomes included interpremolar and intermolar widths, buccal inclination of posterior teeth, and buccal alveolar bone thickness at 3&#xa0;mm. Intragroup changes were analyzed using paired tests; between-group comparisons were performed on change scores, with ANCOVA used to adjust for baseline imbalances where present.</p> Results <p>Both groups demonstrated significant transverse increases; however, the test group showed significantly greater predictability of prescribed interpremolar and intermolar expansion compared with controls (<i>p</i> &lt; 0.001). Buccal tipping of premolars and molars was significantly greater in controls, whereas the test group demonstrated minimal inclination change (<i>p</i> &lt; 0.001). Molar buccal alveolar thickness was relatively preserved in the test group, while a small reduction was observed in controls (<i>p</i> = 0.007).</p> Conclusion <p>Adjunctive photobiomodulation was associated with improved short-term predictability of digitally prescribed transverse expansion during clear aligner therapy, with reduced buccal tipping and relative preservation of molar buccal alveolar thickness. These findings likely reflect differences in biological response influencing the predictability of planned movements and should be considered hypothesis-generating.</p> Trial registration <p>Clinical Trials RegistryIndia (CTRI <a href="https://ctri.nic.in">https://ctri.nic.in</a>), Registration No. CTRI/2024/08/072889.</p>

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Adjunctive photobiomodulation and predictability of digitally prescribed transverse expansion in clear aligner therapy: a pilot randomized clinical trial

  • 期刊论文

  • 发表日期：

    2026年3月26日

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  • Udit Chaudhary,
  • Achint Juneja,
  • Monis Raza,
  • Akansha Budakoti,
  • Prachi Mehra,
  • Shraddha Bhalla

摘要

Purpose

To evaluate whether adjunctive photobiomodulation (PBM) improves the predictability of digitally prescribed transverse expansion during clear aligner therapy.

Methods

In this single-center pilot randomized clinical trial, 30 participants undergoing clear aligner therapy were randomized to aligners alone (control) or aligners with adjunctive photobiomodulation (test). Identical digitally prescribed transverse expansion was planned for both groups. Cone-beam computed tomography (CBCT) and digital models were obtained at baseline (T0) and after completion of a 14-aligner protocol (T1). Outcomes included interpremolar and intermolar widths, buccal inclination of posterior teeth, and buccal alveolar bone thickness at 3 mm. Intragroup changes were analyzed using paired tests; between-group comparisons were performed on change scores, with ANCOVA used to adjust for baseline imbalances where present.

Results

Both groups demonstrated significant transverse increases; however, the test group showed significantly greater predictability of prescribed interpremolar and intermolar expansion compared with controls (p < 0.001). Buccal tipping of premolars and molars was significantly greater in controls, whereas the test group demonstrated minimal inclination change (p < 0.001). Molar buccal alveolar thickness was relatively preserved in the test group, while a small reduction was observed in controls (p = 0.007).

Conclusion

Adjunctive photobiomodulation was associated with improved short-term predictability of digitally prescribed transverse expansion during clear aligner therapy, with reduced buccal tipping and relative preservation of molar buccal alveolar thickness. These findings likely reflect differences in biological response influencing the predictability of planned movements and should be considered hypothesis-generating.

Trial registration

Clinical Trials RegistryIndia (CTRI https://ctri.nic.in), Registration No. CTRI/2024/08/072889.