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Objective <p>To evaluate the temporal dynamics of Substance P (SP) regulation following photobiomodulation (PBM) in an orthodontic inflammation model, and to explore the implications of delayed immunological response kinetics.</p> Materials and methods <p>A randomized split-mouth design was implemented in orthodontic patients receiving low-level laser therapy (PBM). SP concentrations were quantified using ELISA at baseline, 24 hours post-irradiation, and following a second PBM dose. Technical validation included wavelength extrapolation and duplicate sampling to ensure reproducibility.</p> Results <p>SP levels decreased at 24 hours post-PBM, followed by a subsequent increase after the second irradiation. This oscillatory pattern suggests a non-linear regulatory trajectory, consistent with delayed neuroimmune processing. The findings suggest a temporal dissociation between clinical symptom relief and molecular biomarker behavior.</p> Conclusion <p>This pilot study suggests that photobiomodulation (PBM) with an 810 nm diode laser may modulate neuropeptide expression during the initial phase of orthodontic force application.</p>

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Modulation of substance P in gingival crevicular fluid following 810 nm photobiomodulation during early orthodontic force application: a pilot study

  • 期刊论文

  • 发表日期：

    2026年1月5日

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  • Sergio Andrés Velásquez ,
  • Liliana López Anaya,
  • Angela Domínguez,
  • Farid Alfonso Dipp Velázquez,
  • Brenda Eréndida Castillo Silva

摘要

Objective

To evaluate the temporal dynamics of Substance P (SP) regulation following photobiomodulation (PBM) in an orthodontic inflammation model, and to explore the implications of delayed immunological response kinetics.

Materials and methods

A randomized split-mouth design was implemented in orthodontic patients receiving low-level laser therapy (PBM). SP concentrations were quantified using ELISA at baseline, 24 hours post-irradiation, and following a second PBM dose. Technical validation included wavelength extrapolation and duplicate sampling to ensure reproducibility.

Results

SP levels decreased at 24 hours post-PBM, followed by a subsequent increase after the second irradiation. This oscillatory pattern suggests a non-linear regulatory trajectory, consistent with delayed neuroimmune processing. The findings suggest a temporal dissociation between clinical symptom relief and molecular biomarker behavior.

Conclusion

This pilot study suggests that photobiomodulation (PBM) with an 810 nm diode laser may modulate neuropeptide expression during the initial phase of orthodontic force application.