<p>Hispanic/Latino workers in lower-status jobs are disproportionately exposed to physical hazards, whereas those in higher-status occupations contend with widespread experiences of interpersonal discrimination. However, studies have not considered the extent to which occupational injustices have distinct health impacts on Hispanic/Latino workers across occupational statuses. This study examined the associations of physical hazards (e.g., fumes, gas, solvents) and workplace discrimination with physical and mental health-related quality of life (HRQoL) in a multi-site sample of Hispanic/Latino workers (<i>N</i> = 2,114) from the Hispanic Community Health Study/Study of Latinos (HCHS/SOL) and its Sociocultural Ancillary Study (SCAS). Survey-weighted linear regressions revealed that greater exposure to physical hazards predicted worse physical HRQoL, and workplace discrimination predicted worse physical and mental HRQoL. Occupational status moderated the association between workplace discrimination and mental HRQoL; this association was stronger for lower-status Hispanic/Latino workers. The interaction between occupational status and physical hazards was not significant. Additionally, the interaction between physical hazards and workplace discrimination on mental HRQoL was significant, with physical hazards especially impacting workers reporting low or moderate levels of workplace discrimination. These findings underscore the need to consider exposure to both social and physical occupational hazards and emphasize the importance of individual differences in occupational status when focusing on workers' mental and physical HRQoL. Findings may inform organizational policies and interventions to reduce work-based health disparities impacting Hispanic/Latino workers, the fastest-growing segment of the US labor force.</p>