<p>Cancer is the second leading cause of mortality globally. Radiation therapy is a critical technological approach in oncology treatment and includes conventional dose rate radiation therapy, high-dose radiotherapy, and ultrahigh-dose rate radiation therapy. Following the significant increase in radiotherapy dose rates, real-time dosimetry monitoring faces the dual challenge of enhancing both response time and measurement precision. In this study, we successfully developed a real-time dosimetry monitoring system for radiotherapy designed to accommodate a broad range of dose rates. The system consists of a dual-gated, integrator architecture, front-end and high-speed data acquisition circuit, providing accurate detection of bipolar current pulse signals with peak values from <InlineEquation ID="IEq1"> <EquationSource Format="TEX">$-190$</EquationSource> <EquationSource Format="MATHML"><math> <mrow> <mo>-</mo> <mn>190</mn> </mrow> </math></EquationSource> </InlineEquation> μA to +200 μA. The minimum current measurement range is <InlineEquation ID="IEq3"> <EquationSource Format="TEX">$-1$</EquationSource> <EquationSource Format="MATHML"><math> <mrow> <mo>-</mo> <mn>1</mn> </mrow> </math></EquationSource> </InlineEquation> pA to +1 pA. Two major technological advancements were accomplished: First, the elimination of the signal processing dead time resulted in a reduction of the single-event readout time to 5 μs; second, the nonlinear error (ranging from <InlineEquation ID="IEq5"> <EquationSource Format="TEX">$-190$</EquationSource> <EquationSource Format="MATHML"><math> <mrow> <mo>-</mo> <mn>190</mn> </mrow> </math></EquationSource> </InlineEquation> μA up to the maximum current value) is within 0.67<InlineEquation ID="IEq6"> <EquationSource Format="TEX">$\%$</EquationSource> <EquationSource Format="MATHML"><math> <mo>%</mo> </math></EquationSource> </InlineEquation>, with a linear correlation coefficient (<InlineEquation ID="IEq7"> <EquationSource Format="TEX">$R^2$</EquationSource> <EquationSource Format="MATHML"><math> <msup> <mi>R</mi> <mn>2</mn> </msup> </math></EquationSource> </InlineEquation>) of 0.99992. Experiments were conducted using an ionization chamber detector at the Heavy Ion Research Facility in Lanzhou. This system, combined with a dose detector, achieves real-time dose measurements within the dose rate range of 65–<InlineEquation ID="IEq8"> <EquationSource Format="TEX">${120}\,\hbox {Gy/min}$</EquationSource> <EquationSource Format="MATHML"><math> <mrow> <mn>120</mn> <mspace width="0.166667em" /> <mtext>Gy/min</mtext> </mrow> </math></EquationSource> </InlineEquation>. Excellent real-time monitoring performance is demonstrated in the high-dose range of radiation therapy, demonstrating the system’s potential for additional use in dose monitoring for electron- and proton-beam radiotherapy applications.</p>

Development of an innovative real-time dosimetry monitoring system for heavy-ion radiotherapy

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发表日期：

2026年5月18日

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Ling-Ling Liu,
Qian-Shun She,
Jie Kong,
Jun-Wei Yan,
Yu-Han Dou

摘要

Cancer is the second leading cause of mortality globally. Radiation therapy is a critical technological approach in oncology treatment and includes conventional dose rate radiation therapy, high-dose radiotherapy, and ultrahigh-dose rate radiation therapy. Following the significant increase in radiotherapy dose rates, real-time dosimetry monitoring faces the dual challenge of enhancing both response time and measurement precision. In this study, we successfully developed a real-time dosimetry monitoring system for radiotherapy designed to accommodate a broad range of dose rates. The system consists of a dual-gated, integrator architecture, front-end and high-speed data acquisition circuit, providing accurate detection of bipolar current pulse signals with peak values from $-190$ $- 190$ μA to +200 μA. The minimum current measurement range is $-1$ $- 1$ pA to +1 pA. Two major technological advancements were accomplished: First, the elimination of the signal processing dead time resulted in a reduction of the single-event readout time to 5 μs; second, the nonlinear error (ranging from $-190$ $- 190$ μA up to the maximum current value) is within 0.67 $\%$ $%$ , with a linear correlation coefficient ( $R^2$ $R^{2}$ ) of 0.99992. Experiments were conducted using an ionization chamber detector at the Heavy Ion Research Facility in Lanzhou. This system, combined with a dose detector, achieves real-time dose measurements within the dose rate range of 65– ${120}\,\hbox {Gy/min}$ $120 Gy/min$ . Excellent real-time monitoring performance is demonstrated in the high-dose range of radiation therapy, demonstrating the system’s potential for additional use in dose monitoring for electron- and proton-beam radiotherapy applications.