Scholarlink

<p>This study aimed to identify the chemical constituents of the ethanolic extract of <i>C. serrulata</i>, evaluate its antidiabetic and genoprotective properties in diabetic mice as well as perform in silico ADME and drug-likeness evaluation. Thalassiolin D, diosmetin 7-<i>O</i>-<i>β</i>-glucoside, diosmetin, luteolin 7-<i>O</i>-<i>β</i>-glucoside, kaempferol 3-<i>O</i>-<i>β</i>-glucoside, kaempferol, rutin, quercitrin, caffeic acid, ferulic acid, protocatechuic acid and sinapoyl malate were isolated and identified by chromatographic and spectroscopic methods for the first time in this species. In diabetic mice, oral administration of the extract reduced blood glucose levels by 57, 65 and 50% at doses of 50, 100 and 200&#xa0;mg/kg b.wt., respectively, in comparison with metformin (62%). At the tested doses, the extract also alleviated diabetes-induced genotoxicity and significantly reduced abnormal chromosomes in germ cells with 10, 36, and 48% and bone marrow cells with 12, 26, and 53%. The identified compounds have two common targets in diabetes-involved genes: carbonic anhydrase 2 and aldehyde reductase. These findings may motivate research, evaluation, formulation, and application studies regarding <i>C. serrulata</i> as a potential nutraceutical source for managing diabetes and its complications.</p> Graphical Abstract <p></p>

错误：搜索内容不能为空，请输入英文关键词
错误：关键词超出字数限制，请精简
高级检索

Antidiabetic, Genoprotective Potential, and Phytoconstituents of Cymodocea serrulata (R. Brown): In vivo, Drug Target Prediction, and ADME Studies

  • 期刊论文

  • 发表日期：

    2025年2月1日

查看全文
  • Sahar El-Souda,
  • Usama W. Hawas,
  • Lamia T. Abou El-Kassem,
  • Zeinab Hassan,
  • Maha Fahmy,
  • Ayman Farghaly,
  • Mohamed A. Tantawy

摘要

This study aimed to identify the chemical constituents of the ethanolic extract of C. serrulata, evaluate its antidiabetic and genoprotective properties in diabetic mice as well as perform in silico ADME and drug-likeness evaluation. Thalassiolin D, diosmetin 7-O-β-glucoside, diosmetin, luteolin 7-O-β-glucoside, kaempferol 3-O-β-glucoside, kaempferol, rutin, quercitrin, caffeic acid, ferulic acid, protocatechuic acid and sinapoyl malate were isolated and identified by chromatographic and spectroscopic methods for the first time in this species. In diabetic mice, oral administration of the extract reduced blood glucose levels by 57, 65 and 50% at doses of 50, 100 and 200 mg/kg b.wt., respectively, in comparison with metformin (62%). At the tested doses, the extract also alleviated diabetes-induced genotoxicity and significantly reduced abnormal chromosomes in germ cells with 10, 36, and 48% and bone marrow cells with 12, 26, and 53%. The identified compounds have two common targets in diabetes-involved genes: carbonic anhydrase 2 and aldehyde reductase. These findings may motivate research, evaluation, formulation, and application studies regarding C. serrulata as a potential nutraceutical source for managing diabetes and its complications.

Graphical Abstract