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<p>Extracts from the species <i>Teucrium polium L</i> are compounds used in many fields such as aromatherapy and phytopathology. These extracts are sensitive to air and light, making them very difficult to be used as active ingredients in medicines. This prompted us to develop and formulate an innovative approach to protect these compounds, such as nanoemulsions, which are currently experiencing rapid growth. The main objective of this study was to develop a nanoemulsion containing chemical components extracted from the aerial parts of <i>Teucrium polium L</i> and to explore their therapeutic potential through application in patch form. The nanoemulsion (NE) was developed by spontaneous emulsification. Dynamic light scattering (DLS) analysis on the formulation showed the particle size of 42&#xa0;nm ± 2.45, with a zeta potential of 53.2 mV ± 0.3 and a polydispersity index (PI) of 0.339 ± 0.02. Rheological analyses were performed to study the behavior of the nanoemulsion. A stable patch was optimized and developed, and its physicochemical properties were examined by Fourier transform infrared spectroscopy (FTIR). It demonstrated controlled release of the nanoemulsion, with 33.3% released in the first 15&#xa0;min and 87% after 24&#xa0;h, indicating its potential effectiveness as a topical drug delivery system. In addition, the healing activity was evaluated and studied on Wistar rats using an ethanolic extract of <i>Teucrium polium L</i> and a Cicatryl bio cream as a reference. The healing properties of the extract were superior to those of the Cicatryl bio reference from the 18th day onwards, with a 98.04% reduction in wound size compared to 91% for the reference cream.</p>

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Development and healing potential of a transdermal patch with nanoemulsion from Teucrium polium L. ethanolic extract

  • 期刊论文

  • 发表日期：

    2026年1月8日

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  • Zineb Timizar,
  • Amel Hadj Ziane Zafour,
  • Ibtessem Rahim,
  • Sabrina Lekmine,
  • Hassiba Laribi,
  • Mouhamed Laide Telili,
  • Khalida Boutemak,
  • Asma Belkadi,
  • Nesrine Lina Gharnaout,
  • Nabil Touzout,
  • Amel Boudjelal,
  • Jie Zhang,
  • Abdeltif Amrane,
  • Hichem Tahraoui

摘要

Extracts from the species Teucrium polium L are compounds used in many fields such as aromatherapy and phytopathology. These extracts are sensitive to air and light, making them very difficult to be used as active ingredients in medicines. This prompted us to develop and formulate an innovative approach to protect these compounds, such as nanoemulsions, which are currently experiencing rapid growth. The main objective of this study was to develop a nanoemulsion containing chemical components extracted from the aerial parts of Teucrium polium L and to explore their therapeutic potential through application in patch form. The nanoemulsion (NE) was developed by spontaneous emulsification. Dynamic light scattering (DLS) analysis on the formulation showed the particle size of 42 nm ± 2.45, with a zeta potential of 53.2 mV ± 0.3 and a polydispersity index (PI) of 0.339 ± 0.02. Rheological analyses were performed to study the behavior of the nanoemulsion. A stable patch was optimized and developed, and its physicochemical properties were examined by Fourier transform infrared spectroscopy (FTIR). It demonstrated controlled release of the nanoemulsion, with 33.3% released in the first 15 min and 87% after 24 h, indicating its potential effectiveness as a topical drug delivery system. In addition, the healing activity was evaluated and studied on Wistar rats using an ethanolic extract of Teucrium polium L and a Cicatryl bio cream as a reference. The healing properties of the extract were superior to those of the Cicatryl bio reference from the 18th day onwards, with a 98.04% reduction in wound size compared to 91% for the reference cream.