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<p>This study evaluates the antilithiatic effects of a hydromethanolic extract from the aerial parts of <i>Polygonum maritimum</i> in a rat model of urinary lithiasis induced by 0.75% ethylene glycol (EG) in drinking water. It was clear that following ethylene glycol treatment a hypercalcemia (<i>p</i> &lt; 0.0001), a hyperoxaluria (<i>p</i> &lt; 0.0001), an increase in urinary acidity (<i>p</i> &lt; 0.001), and a reduction in urinary volume (<i>p</i> &lt; 0.0001) were detected at both 14 and 28 days. It was interesting that when administered, <i>P. maritimum</i> extract significantly reduced the elevated levels of creatinine, bilirubin, urea, and uric acid. At a dose of 37.5&#xa0;mg/kg, the reductions were 55%, 62%, 40%, and 38%, respectively, while at 50&#xa0;mg/kg, the reductions were 75%, 63%, 60%, and 64%. This treatment also decreased crystal accumulation in the renal tubules and improved their structural integrity. Microscopic observation showed that <i>P. maritimum</i> extract administration clearly reduced the large urinary crystal formations and oxalate clusters resulting from ethylene glycol exposure. A molecular docking study revealed that the procyanidin and quercetin pentoside compounds present in <i>P. maritimum</i> display potential inhibitory effects through hydrogen-bonding interactions with Neutrophil Gelatinase-Associated Lipocalin (NGAL) and Myéloperoxydase (MPO), key proteins involved in nephropathy and urinary crystal formation. This study highlights the therapeutic potential of <i>P. maritimum</i> and supports its anti-urolithiatic and nephroprotective effects via mechanisms targeting alleviation of oxidative stress and inflammation.</p> Graphical Abstract <p></p>

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Biomolecules from Polygonum maritimum mitigate ethylene glycol-induced urolithiasis: insights from in vivo and molecular docking studies

  • 期刊论文

  • 发表日期：

    2025年12月18日

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  • Abir Najahi,
  • Akram Alaya,
  • Mabrouk Horchani,
  • Afoua Mufti,
  • Meriam Tir,
  • Anouar Feriani,
  • Wael Bahia,
  • Nizar Tlili

摘要

This study evaluates the antilithiatic effects of a hydromethanolic extract from the aerial parts of Polygonum maritimum in a rat model of urinary lithiasis induced by 0.75% ethylene glycol (EG) in drinking water. It was clear that following ethylene glycol treatment a hypercalcemia (p < 0.0001), a hyperoxaluria (p < 0.0001), an increase in urinary acidity (p < 0.001), and a reduction in urinary volume (p < 0.0001) were detected at both 14 and 28 days. It was interesting that when administered, P. maritimum extract significantly reduced the elevated levels of creatinine, bilirubin, urea, and uric acid. At a dose of 37.5 mg/kg, the reductions were 55%, 62%, 40%, and 38%, respectively, while at 50 mg/kg, the reductions were 75%, 63%, 60%, and 64%. This treatment also decreased crystal accumulation in the renal tubules and improved their structural integrity. Microscopic observation showed that P. maritimum extract administration clearly reduced the large urinary crystal formations and oxalate clusters resulting from ethylene glycol exposure. A molecular docking study revealed that the procyanidin and quercetin pentoside compounds present in P. maritimum display potential inhibitory effects through hydrogen-bonding interactions with Neutrophil Gelatinase-Associated Lipocalin (NGAL) and Myéloperoxydase (MPO), key proteins involved in nephropathy and urinary crystal formation. This study highlights the therapeutic potential of P. maritimum and supports its anti-urolithiatic and nephroprotective effects via mechanisms targeting alleviation of oxidative stress and inflammation.

Graphical Abstract