Scholarlink

<p>The strawberry tree (<i>Arbutus unedo</i> L.) has been used in traditional natural healing practices for centuries, particularly in Mediterranean regions. This work investigates the bioactive potential of <i>A. unedo</i> leaves collected from the ‘Guelma’ region (Algeria). Phytochemical screening confirmed that the aqueous extract contained high levels of polyphenols, flavonoids, and proanthocyanidins, demonstrating significant antioxidant activity (DPPH IC<sub>50</sub> = 95.4&#xa0;μg/mL; total antioxidant activity: 85.11 ± 0.09&#xa0;mg GAE/g DE). The extract exhibited potent antibacterial effects, particularly against Gram-positive bacteria, and inhibited mushroom tyrosinase, suggesting dermatological applications. Interestingly, it displayed anti-inflammatory properties by suppressing pro-inflammatory nitric oxide (NO) production (IC<sub>50</sub> = 60.87 ± 0.33&#xa0;µg/mL). Cytotoxicity assays revealed no adverse effects on RAW 264.7 macrophage cells (LC₅₀ = 732.88 ± 1.5&#xa0;µg/mL), with a favorable selectivity index (SI = 12). Through TLC-bioautography and GC–MS analysis, arbutin was identified as the primary active compound. Given these findings, the aqueous leaf extract of <i>A. unedo</i> shows promise as a natural preservative for the food industry, as well as a functional ingredient for pharmaceutical and cosmetic formulations.</p>

错误：搜索内容不能为空，请输入英文关键词
错误：关键词超出字数限制，请精简
高级检索

Algerian Arbutus unedo (L.) leaves: phytochemicals, biological activities, and GC–MS identification of the TMS-derivatized antibacterial agent

  • 期刊论文

  • 发表日期：

    2025年9月19日

查看全文
  • Saida Medjeldi,
  • Rym Essid,
  • Radia Djelloul,
  • Bilel Damergi,
  • Nadia Fares,
  • Sélim Jellouli,
  • Mohamed Mousli,
  • Olfa Tabbene

摘要

The strawberry tree (Arbutus unedo L.) has been used in traditional natural healing practices for centuries, particularly in Mediterranean regions. This work investigates the bioactive potential of A. unedo leaves collected from the ‘Guelma’ region (Algeria). Phytochemical screening confirmed that the aqueous extract contained high levels of polyphenols, flavonoids, and proanthocyanidins, demonstrating significant antioxidant activity (DPPH IC50 = 95.4 μg/mL; total antioxidant activity: 85.11 ± 0.09 mg GAE/g DE). The extract exhibited potent antibacterial effects, particularly against Gram-positive bacteria, and inhibited mushroom tyrosinase, suggesting dermatological applications. Interestingly, it displayed anti-inflammatory properties by suppressing pro-inflammatory nitric oxide (NO) production (IC50 = 60.87 ± 0.33 µg/mL). Cytotoxicity assays revealed no adverse effects on RAW 264.7 macrophage cells (LC₅₀ = 732.88 ± 1.5 µg/mL), with a favorable selectivity index (SI = 12). Through TLC-bioautography and GC–MS analysis, arbutin was identified as the primary active compound. Given these findings, the aqueous leaf extract of A. unedo shows promise as a natural preservative for the food industry, as well as a functional ingredient for pharmaceutical and cosmetic formulations.