Scholarlink

<p>Diarrhea is among the common diseases affecting camel calves less than 3&#xa0;months old resulting in a high mortality rate and has devastating effects on the economic success of camel production. <i>Escherichia coli</i> (<i>E.coli</i>) strains exhibiting F17 fimbriae are frequently detected in diarrheic animals. This study aimed to investigate the pathogenic mechanisms of <i>E.coli</i> F17 + infection in camel calves. Three 3-day-old camel calves were experimentally infected with 10⁸ CFU of <i>E.coli</i> F17 + . Prior to inoculation, none of the animals was infected with <i>E.coli</i> as screened with polymerase chain reaction (PCR). Daily health status and fecal consistency were recorded individually by a point scale. Although experimental infection with <i>E.coli</i> F17 + revealed that camel calves developed signs of lethargy, loss of appetite, and dehydration from the first day after inoculation, diarrhea did not appear in challenged animals. Histological analysis showed lesions marked essentially by destruction of villous enterocytes and villous atrophy in small intestines and infiltration predominantly by polymorphonuclear leucocytes; despite the absence of diarrhea. Immunohistology examination showed adherence of <i>E.coli</i> F17 + strain to intestinal enterocytes in inoculated animals. These findings provide a clearer understanding of the pathogenisis of <i>E.coli</i> in camel calves, which could guide the development of preventive health measures aimed at improving camel productivity and ensure in pastoral economies.</p>

错误：搜索内容不能为空，请输入英文关键词
错误：关键词超出字数限制，请精简
高级检索

Pathogenicity of Escherichia coli positive for F17 fimbriae in neonatal camel calve after oral inoculation

  • 期刊论文

  • 发表日期：

    2025年8月25日

查看全文
  • Salma Bessalah,
  • Mouldi Mabrouk Seddik,
  • Imed Salhi,
  • Mohamed Hammadi,
  • Touhami Khorchani,
  • Abdelmajid Khabir

摘要

Diarrhea is among the common diseases affecting camel calves less than 3 months old resulting in a high mortality rate and has devastating effects on the economic success of camel production. Escherichia coli (E.coli) strains exhibiting F17 fimbriae are frequently detected in diarrheic animals. This study aimed to investigate the pathogenic mechanisms of E.coli F17 + infection in camel calves. Three 3-day-old camel calves were experimentally infected with 10⁸ CFU of E.coli F17 + . Prior to inoculation, none of the animals was infected with E.coli as screened with polymerase chain reaction (PCR). Daily health status and fecal consistency were recorded individually by a point scale. Although experimental infection with E.coli F17 + revealed that camel calves developed signs of lethargy, loss of appetite, and dehydration from the first day after inoculation, diarrhea did not appear in challenged animals. Histological analysis showed lesions marked essentially by destruction of villous enterocytes and villous atrophy in small intestines and infiltration predominantly by polymorphonuclear leucocytes; despite the absence of diarrhea. Immunohistology examination showed adherence of E.coli F17 + strain to intestinal enterocytes in inoculated animals. These findings provide a clearer understanding of the pathogenisis of E.coli in camel calves, which could guide the development of preventive health measures aimed at improving camel productivity and ensure in pastoral economies.