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<p>Nanomaterials have been receiving increased attention recently due to their wide range of applications in applied scientific fields, including medicine, environmental science, and engineering. However, the synthesis of nanomaterials through chemical methods was time-consuming, expensive, and hazardous to the environment. This prompted researchers to adopt safer methods known as biosynthesis, which is considered eco-friendly and more biocompatible. In this study, the biosynthesis of cupric oxide nanoparticles was carried out using the aqueous flower extract of <i>Bauhinia purpurea</i>. The plant phytochemicals, such as phenols and flavonoids, acted as reducing and stabilizing agents for the nanoparticles. Nanoparticles were characterized with ultraviolet visible spectroscopy, Fourier transform infrared spectroscopy, X-ray Diffraction, scanning electron microscopy, and transmission electron microscopy. The synthesized BP-CuONPs showed particle sizes ranging from approximately 30–50&#xa0;nm by SEM and TEM analysis, with a hydrodynamic size of ~ 200&#xa0;nm by DLS and surface charge of -19 mV. The nanoparticles showed moderate antioxidant activity in both DPPH and metal chelating activity, with IC50 335.41 and 73.1&#xa0;µg/ml, respectively. The MTT assay was also conducted to investigate the cytotoxicity of the nanoparticles using neuroblastoma and Vero cell lines. Moreover, the seed germination parameters were enhanced by applying the optimal concentration of the nanoparticles. This highlights the significance of the phytomediated BP-CuONPs and provides new possibilities for their expanded use in applied environmental sciences.</p> Graphical abstract <p></p>

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Unravelling metal chelating activity, cytotoxicity, and seed germination of phytomediated cupric oxide nanoparticles

  • 期刊论文

  • 发表日期：

    2026年6月2日

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  • Alaa Kayali,
  • Infant Santhose Barthelomai,
  • Subhash Bharathi S,
  • Gideon Paul Kingsly Jesurajan,
  • Mohammed Ali Najjar

摘要

Nanomaterials have been receiving increased attention recently due to their wide range of applications in applied scientific fields, including medicine, environmental science, and engineering. However, the synthesis of nanomaterials through chemical methods was time-consuming, expensive, and hazardous to the environment. This prompted researchers to adopt safer methods known as biosynthesis, which is considered eco-friendly and more biocompatible. In this study, the biosynthesis of cupric oxide nanoparticles was carried out using the aqueous flower extract of Bauhinia purpurea. The plant phytochemicals, such as phenols and flavonoids, acted as reducing and stabilizing agents for the nanoparticles. Nanoparticles were characterized with ultraviolet visible spectroscopy, Fourier transform infrared spectroscopy, X-ray Diffraction, scanning electron microscopy, and transmission electron microscopy. The synthesized BP-CuONPs showed particle sizes ranging from approximately 30–50 nm by SEM and TEM analysis, with a hydrodynamic size of ~ 200 nm by DLS and surface charge of -19 mV. The nanoparticles showed moderate antioxidant activity in both DPPH and metal chelating activity, with IC50 335.41 and 73.1 µg/ml, respectively. The MTT assay was also conducted to investigate the cytotoxicity of the nanoparticles using neuroblastoma and Vero cell lines. Moreover, the seed germination parameters were enhanced by applying the optimal concentration of the nanoparticles. This highlights the significance of the phytomediated BP-CuONPs and provides new possibilities for their expanded use in applied environmental sciences.

Graphical abstract