Green Synthesis, characterization, antimicrobial and anticancer properties of iron oxide nanoparticles mediated by Annona muricata (sour sop) leaf extract

In this research, the synthesis, characterization, antimicrobial, and anticancer properties of iron oxide-nanoparticles were carried out in the presence of a bioreductant (Annona muricata). The preliminary formation of the iron oxide nanoparticles was investigated with an Ultra violet-Visible spectroscopy (UV) with absorption observed at wavelength of 236 nm. The X-ray diffraction (XRD) studies revealed peaks characteristic of Fe₂O₃, FeO₂ and FeOOH. The nanoparticles showed elemental composition of C (32.1%), O (9.13%), Cl (32.36%), K (1.21%), Ca (1.03%) and Fe (24.16%). The microscopic studies showed spherical morphology and particle size of 4.19 nm. The antimicrobial analysis carried out revealed that some of the microorganisms were sensitive to the nanoparticles and are good antimicrobial agents. The anticancer analysis using normal HEK 293 cells and Hela carcinoma showed cell death of 50% at concentration of 63. 05 µg/mL for the HEK 293 cells and concentration of 48.97 µg/mL for the Hela cells.