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<p>Viral infections pose significant global health challenges, underscoring the need for precise and rapid detection methods. Graphene, known for its exceptional physicochemical properties, has emerged as a promising material for biosensing. This study explores the use of bilayer graphene (BLG) as a sensitive platform for detecting human papilloma virus (HPV). Due to its tunable electronic properties and enhanced surface reactivity, BLG offers advantages over monolayer graphene in biosensing applications. Atomistic finite element method (AFEM) simulations using ANSYS were conducted to assess BLG's vibrational response to HPV masses ranging from 4.49 × 10−<sup>20</sup>g to 1.1673 × 10−<sup>20</sup>g under bridged boundary conditions. Both pristine and defected models were analyzed, focusing on the influence of atomic vacancies. Results revealed that zigzag configurations exhibited superior sensitivity compared to armchair ones, with 75 nm pristine BLG showing the highest vibrational frequency. The study highlights BLG’s potential for developing high-sensitivity biosensors, offering improved accuracy and faster detection. These findings suggest a promising direction for advancing viral diagnostics and overcoming current limitations in disease detection technologies. </p>

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Advanced biosensing of human papilloma virus using bilayer graphene

  • 期刊论文

  • 发表日期：

    2025年5月22日

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  • Manisha V. Makwana

摘要

Viral infections pose significant global health challenges, underscoring the need for precise and rapid detection methods. Graphene, known for its exceptional physicochemical properties, has emerged as a promising material for biosensing. This study explores the use of bilayer graphene (BLG) as a sensitive platform for detecting human papilloma virus (HPV). Due to its tunable electronic properties and enhanced surface reactivity, BLG offers advantages over monolayer graphene in biosensing applications. Atomistic finite element method (AFEM) simulations using ANSYS were conducted to assess BLG's vibrational response to HPV masses ranging from 4.49 × 10−20g to 1.1673 × 10−20g under bridged boundary conditions. Both pristine and defected models were analyzed, focusing on the influence of atomic vacancies. Results revealed that zigzag configurations exhibited superior sensitivity compared to armchair ones, with 75 nm pristine BLG showing the highest vibrational frequency. The study highlights BLG’s potential for developing high-sensitivity biosensors, offering improved accuracy and faster detection. These findings suggest a promising direction for advancing viral diagnostics and overcoming current limitations in disease detection technologies.