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Purpose <p>Previous studies have suggested a relationship between obstructive sleep apnea (OSA) and metabolic syndrome (MetS). Aging affects the prevalence of OSA and MetS and the relationship between them. However, whether a relationship between OSA and MetS can be observed in elderly and non-elderly Japanese patients remains unclear.</p> Methods <p>Data from patients diagnosed with OSA using overnight polysomnography were analyzed. All patients were divided into two groups by age: &lt;60 or ≥ 60 years. The coexistence of MetS, determined according to the Japanese criteria, was compared across the severity of OSA.</p> Results <p>In 338 patients aged &lt; 60 years including 182 with severe OSA, MetS prevalence increased with OSA severity (13.3% in mild, 31.5% in moderate, and 46.7% in severe; <i>P</i> &lt; 0.001). In 145 patients aged ≥ 60 years including 68 with severe OSA, MetS prevalence also increased with OSA severity (16.0% in mild, 28.8% in moderate, and 45.6% in severe; <i>P</i> = 0.016). There was no interaction between age group and the OSA severity/MetS relationship, suggesting that the relationship between OSA severity and MetS was similar in the non-elderly and elderly groups. In the adjusted analysis of patients aged &lt; 60 years, severe OSA was associated with a higher risk of MetS compared to mild OSA (odds ratio [OR], 3.9; 95% confidence interval [CI, 1.5–10.0]); in those aged ≥ 60 years, severe OSA had a non-significant tendency to be associated with MetS (OR, 2.9; 95%CI, 0.8–10.1).</p> Conclusions <p>MetS prevalence increased with OSA severity in this population, and the associations were similar in elderly and non-elderly Japanese patients.</p>

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Effects of age on association between obstructive sleep apnea and metabolic syndrome in the Japanese patient population

  • 期刊论文

  • 发表日期：

    2026年7月8日

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  • Keisuke Kataoka,
  • Tomotaka Dohi,
  • Takatoshi Kasai,
  • Hisashi Takaya,
  • Satoshi Kasagi,
  • Yasuhiro Tomita,
  • Ryo Naito,
  • Koji Narui

摘要

Purpose

Previous studies have suggested a relationship between obstructive sleep apnea (OSA) and metabolic syndrome (MetS). Aging affects the prevalence of OSA and MetS and the relationship between them. However, whether a relationship between OSA and MetS can be observed in elderly and non-elderly Japanese patients remains unclear.

Methods

Data from patients diagnosed with OSA using overnight polysomnography were analyzed. All patients were divided into two groups by age: <60 or ≥ 60 years. The coexistence of MetS, determined according to the Japanese criteria, was compared across the severity of OSA.

Results

In 338 patients aged < 60 years including 182 with severe OSA, MetS prevalence increased with OSA severity (13.3% in mild, 31.5% in moderate, and 46.7% in severe; P < 0.001). In 145 patients aged ≥ 60 years including 68 with severe OSA, MetS prevalence also increased with OSA severity (16.0% in mild, 28.8% in moderate, and 45.6% in severe; P = 0.016). There was no interaction between age group and the OSA severity/MetS relationship, suggesting that the relationship between OSA severity and MetS was similar in the non-elderly and elderly groups. In the adjusted analysis of patients aged < 60 years, severe OSA was associated with a higher risk of MetS compared to mild OSA (odds ratio [OR], 3.9; 95% confidence interval [CI, 1.5–10.0]); in those aged ≥ 60 years, severe OSA had a non-significant tendency to be associated with MetS (OR, 2.9; 95%CI, 0.8–10.1).

Conclusions

MetS prevalence increased with OSA severity in this population, and the associations were similar in elderly and non-elderly Japanese patients.