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<p>To evaluate the impact of continuous positive airway pressure (CPAP) therapy on blood pressure (BP) in patients with subacute ischemic stroke and obstructive sleep apnea (OSA). This prospective, non-randomized observational study enrolled 44 patients with subacute ischemic stroke and moderate-to-severe OSA (AHI &gt; 15/h) from a rehabilitation ward between 2015 and 2018. Patients who tolerated CPAP formed the intervention group (<i>n</i> = 25), while those who refused or could not tolerate CPAP served as controls (<i>n</i> = 19). Blood pressure was measured for three consecutive days before and two weeks after the intervention. CPAP efficacy, adherence, and BP outcomes were compared between groups. The CPAP group showed significant reductions in both morning and evening systolic and diastolic BP, with mean reductions of − 9.3 ± 14.5 mmHg (SBP) and − 4.9 ± 10.1 mmHg (DBP) in the morning, and − 11 ± 8.5 mmHg (SBP) and − 4 ± 8.6 mmHg (DBP) in the evening. In contrast, the control group exhibited BP increases. The CPAP group also demonstrated a substantial reduction in AHI (from 43.0 ± 17.3 to 6.5 ± 4.9 events/h) and high compliance (≥ 70% usage days; average 7.3 ± 1.0&#xa0;h/night). CPAP therapy significantly improves blood pressure control in stroke patients with OSA. These findings support incorporating CPAP into standard post-stroke care protocols to mitigate cardiovascular risk.</p>

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The impact of continuous positive airway pressure on blood pressure in patients with ischemic stroke and obstructive sleep apnea

  • 期刊论文

  • 发表日期：

    2026年2月27日

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  • Po-Hao Chen,
  • Chih-Yu Huang,
  • Chung-Chieh Yu

摘要

To evaluate the impact of continuous positive airway pressure (CPAP) therapy on blood pressure (BP) in patients with subacute ischemic stroke and obstructive sleep apnea (OSA). This prospective, non-randomized observational study enrolled 44 patients with subacute ischemic stroke and moderate-to-severe OSA (AHI > 15/h) from a rehabilitation ward between 2015 and 2018. Patients who tolerated CPAP formed the intervention group (n = 25), while those who refused or could not tolerate CPAP served as controls (n = 19). Blood pressure was measured for three consecutive days before and two weeks after the intervention. CPAP efficacy, adherence, and BP outcomes were compared between groups. The CPAP group showed significant reductions in both morning and evening systolic and diastolic BP, with mean reductions of − 9.3 ± 14.5 mmHg (SBP) and − 4.9 ± 10.1 mmHg (DBP) in the morning, and − 11 ± 8.5 mmHg (SBP) and − 4 ± 8.6 mmHg (DBP) in the evening. In contrast, the control group exhibited BP increases. The CPAP group also demonstrated a substantial reduction in AHI (from 43.0 ± 17.3 to 6.5 ± 4.9 events/h) and high compliance (≥ 70% usage days; average 7.3 ± 1.0 h/night). CPAP therapy significantly improves blood pressure control in stroke patients with OSA. These findings support incorporating CPAP into standard post-stroke care protocols to mitigate cardiovascular risk.