<p>Tensegrity systems, renowned for their lightweight and efficient load transfer, offer potential advantages for bridges in seismic-prone regions; however, their seismic performance remains insufficiently studied. This research investigates the seismic behavior of multiple-mast cable stay tensegrity footbridges, with a particular focus on their applications in high-risk zones, including the Himalayas, Northeast India, and the Western Ghats. The objective is to assess their structural efficiency, dynamic stability, and resilience under live load and earthquake loading. A finite element model was developed in SAP2000 software, utilizing nonlinear truss and beam elements to model tension-only cables, compression struts, and stiffened decks. The methodology included modal analysis, response spectrum analysis, nonlinear pushover analysis, and time-history simulations using site-specific ground motions, conducted in accordance with Eurocode 8. Comparative studies with conventional cable-stay footbridges indicated up to 67 percent weight reduction, improved energy dissipation, and higher ductility ratios in tensegrity systems. Optimization strategies, such as tuned mass damping and adaptive prestressing, further enhanced stiffness, modal frequencies, and seismic resilience. The findings demonstrate that tensegrity footbridges provide higher weight-to-strength efficiency and resilience for seismic-prone areas. However, challenges remain regarding torsional rigidity and live load comfort in longer spans. Future research is recommended on real-time monitoring, adaptive damping, and the integration of smart materials.</p>