<p>Environmental consciousness, protection of natural resources, and sustainable development play an important role in infrastructure works. Multicomponent binder-based concretes with reduced cement content provide a sustainable approach to concrete construction. Taguchi’s approach is used to optimize the design of various supplementary cementitious materials using the L16 (4³) orthogonal array method for multi-component binder-based concrete for M30 and M50 grades. Four factors and four parameters, i.e., 16 different binder mix combinations are made by using fly ash (15%, 20%, 25%, 30%), GGBS (10%, 15%, 20%, 25%), metakaolin (5%, 10%, 15%, 20%), and silica fume as 5% for all the mixes and the remaining as the OPC percentage. The results showed that the 65% OPC + 15% fly ash + 10% GGBS + 5% metakaolin + 5% silica fume as the best performance when considering all three parameters, i.e., for the binder’s highest compressive strength, cost, and carbon emission. In this study, the cost analysis, carbon emission, and compressive strength of concrete in the M30 and M50 grades are predicted as the network input, and the proportions of the binder concrete mix are predicted by ANN as the network output, based on the binder concrete mix performance inversely mapped from the centroid of the ternary diagram. The mix proportions corresponding to the compressive strengths of 30, 40, 50, and 60&#xa0;MPa are determined using the procedure described in this study, and the maximum prediction error, when compared with the experiment, is 9%.</p>