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<p><i>N</i>,<i>N</i>-Dimethylformamide (DMF), as an indispensable and versatile reagent in organic synthesis, has evolved from a traditional solvent to a synthetic building block with rich reactivity. Due to its unique molecular structure, DMF can participate in the construction of various complex organic molecules through multiple reaction pathways under different reaction conditions. Accordingly, this review aims to provide a comprehensive and in-depth summary of the latest research progress in organic synthesis using DMF as a versatile synthon, covering all relevant literature reports published between May 1, 2020, and May 1, 2025. Furthermore, in-depth studies of the underlying reaction mechanisms help to precisely understand the essence of DMF’s involvement in reactions, thereby providing a solid theoretical foundation for optimizing reaction conditions and developing novel reaction pathways. This review serves as a crucial reference guide for expanding the application scope of DMF in organic synthesis and developing more environmentally friendly organic synthesis methods.</p> Graphical Abstract <p></p>

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Recent Progress of N,N-Dimethylformamide (DMF) as Versatile Synthons in Organic Synthesis

  • 期刊论文

  • 发表日期：

    2026年4月9日

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  • Hao Lu,
  • Meng Yu,
  • Xiaohui Tian,
  • Xiaorong Suo,
  • Xiaomei Hei,
  • Juan Yang,
  • Jianqi Yao,
  • Renhua Qiu

摘要

N,N-Dimethylformamide (DMF), as an indispensable and versatile reagent in organic synthesis, has evolved from a traditional solvent to a synthetic building block with rich reactivity. Due to its unique molecular structure, DMF can participate in the construction of various complex organic molecules through multiple reaction pathways under different reaction conditions. Accordingly, this review aims to provide a comprehensive and in-depth summary of the latest research progress in organic synthesis using DMF as a versatile synthon, covering all relevant literature reports published between May 1, 2020, and May 1, 2025. Furthermore, in-depth studies of the underlying reaction mechanisms help to precisely understand the essence of DMF’s involvement in reactions, thereby providing a solid theoretical foundation for optimizing reaction conditions and developing novel reaction pathways. This review serves as a crucial reference guide for expanding the application scope of DMF in organic synthesis and developing more environmentally friendly organic synthesis methods.

Graphical Abstract