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<p>Bio-metal-organic frameworks (bio-MOFs) have emerged as a revolutionary group of hybrid materials distinguished by their exceptional biocompatibility, programmable biodegradability, and host–guest molecular recognition capabilities. This review systematically examines recent advancements in bio-MOF engineering, with particular focus on the innovative synthesis strategies and the structure–property relationships arising from their tunable pore architectures and surface functionalities. The mechanistic foundations of bio-MOFs in targeted drug delivery systems, contrast-enhanced bioimaging, and multifunctional therapeutic interventions combining anti-inflammatory and antibacterial actions are discussed in detail. Finally, in terms of future perspectives, we discuss emerging opportunities in other delivery systems, personalized medicine platforms, and sustainable environmental applications, underscoring the necessity for cross-disciplinary collaboration between materials science and molecular biology to unlock the full potential of these biohybrid systems.</p>

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Prospects, Advances, and Applications of BioMOF-Based Platforms

  • 期刊论文

  • 发表日期：

    2025年8月27日

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  • Fangxia Zhao,
  • Xunnan Wan,
  • Yan Liang,
  • Weidong Liu,
  • Jianqiang Liu,
  • Ying Pan,
  • Alireza Nezamzadeh-Ejhieh,
  • Xiaoxiu Li

摘要

Bio-metal-organic frameworks (bio-MOFs) have emerged as a revolutionary group of hybrid materials distinguished by their exceptional biocompatibility, programmable biodegradability, and host–guest molecular recognition capabilities. This review systematically examines recent advancements in bio-MOF engineering, with particular focus on the innovative synthesis strategies and the structure–property relationships arising from their tunable pore architectures and surface functionalities. The mechanistic foundations of bio-MOFs in targeted drug delivery systems, contrast-enhanced bioimaging, and multifunctional therapeutic interventions combining anti-inflammatory and antibacterial actions are discussed in detail. Finally, in terms of future perspectives, we discuss emerging opportunities in other delivery systems, personalized medicine platforms, and sustainable environmental applications, underscoring the necessity for cross-disciplinary collaboration between materials science and molecular biology to unlock the full potential of these biohybrid systems.