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Introduction <p>Asthma is a complex airways disease that affects over 350-million people worldwide. It is estimated that up to 10% of adults and 2.5% of children with asthma have severe disease, which is associated with reduced physical activity. The introduction of biological therapies has revolutionised the management of severe asthma; however, it remains to be determined whether this translates into improvements in physical activity status.</p> Method <p>This 1-year retrospective study evaluated step-based physical activity (via a smartphone pedometer) in adults with severe asthma (<i>n</i>&#xa0;=&#xa0;20) and two matched sub-groups (<i>n</i>&#xa0;=&#xa0;20 mild asthma and <i>n</i>&#xa0;=&#xa0;20 healthy controls).</p> Results <p>The annual daily step count was significantly less in adults with severe asthma (4698&#xa0;±&#xa0;1927) versus mild asthma (7239&#xa0;±&#xa0;1815) (<i>P</i>&#xa0;=&#xa0;0.009) and healthy controls (8252&#xa0;±&#xa0;2115) (<i>P</i>&#xa0;=&#xa0;0.001). No difference in physical activity was observed between those with mild asthma and healthy controls (<i>P</i>&#xa0;&gt;&#xa0;0.05).</p> Conclusion <p>Despite long-term treatment with biological therapies, physical activity remains significantly lower in adults with severe asthma. The development of personalised evidence-based interventions to promote physical activity in people with severe asthma remains a priority.</p>

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Physical Activity in Adults with Severe Asthma On-Treatment with Biological Therapies: A 1-Year Retrospective Analysis of Real-World Data

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2025年3月20日

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  • Caroline Reilly,
  • Antonios Stavropoulos-Kalinoglou,
  • Daniel Peckham,
  • Ian J. Clifton,
  • Oliver J. Price

摘要

Introduction

Asthma is a complex airways disease that affects over 350-million people worldwide. It is estimated that up to 10% of adults and 2.5% of children with asthma have severe disease, which is associated with reduced physical activity. The introduction of biological therapies has revolutionised the management of severe asthma; however, it remains to be determined whether this translates into improvements in physical activity status.

Method

This 1-year retrospective study evaluated step-based physical activity (via a smartphone pedometer) in adults with severe asthma (n = 20) and two matched sub-groups (n = 20 mild asthma and n = 20 healthy controls).

Results

The annual daily step count was significantly less in adults with severe asthma (4698 ± 1927) versus mild asthma (7239 ± 1815) (P = 0.009) and healthy controls (8252 ± 2115) (P = 0.001). No difference in physical activity was observed between those with mild asthma and healthy controls (P > 0.05).

Conclusion

Despite long-term treatment with biological therapies, physical activity remains significantly lower in adults with severe asthma. The development of personalised evidence-based interventions to promote physical activity in people with severe asthma remains a priority.