<p>This study explores the optimization of sustainable concrete through the integration of glass fiber-reinforced polymer (GFRP) and micro-silica, aiming to enhance mechanical properties, structural performance and environmental sustainability for retrofitting and new construction in seismic and corrosive environments. Thirteen concrete mix designs, incorporating Type II Portland cement, micro-silica (10% cement replacement) and GFRP layers (one or two) applied via wet lay-up, were evaluated through experimental, numerical and environmental assessments. Compressive strength tests showed GFRP confinement increased strength by 39.3–82.6%, achieving a peak of 53.5 MPa for two-layer GFRP designs, while micro-silica enhanced strength by 15.9%. Dynamic analysis under cyclic loads indicated improved natural frequency stability and extended failure times (up to 0.53 s) for GFRP-reinforced mixes. A genetic algorithm optimized the design, recommending 10% micro-silica, two GFRP layers and a 45-degree wrapping angle to balance strength (53.5 MPa), ductility (19,000 micro-strains) and cost (90 monetary units). Life cycle assessment revealed a global warming potential of 335 kg CO₂-eq/m³ for GFRP mixes, slightly higher than micro-silica concrete (328 kg CO₂-eq/m³), but GFRP’s extended service life (75–100 years) and lower maintenance needs enhance sustainability. Durability analysis, using Fick’s Law and CEB-FIP models, confirmed GFRP’s resistance to chloride ingress and creep. Cost–benefit analysis yielded benefit–cost ratios of 3.12–11.81, highlighting economic viability. Practically, GFRP-reinforced concrete offers a durable, high-performance solution for infrastructure like bridges and coastal structures, reducing maintenance costs and enabling resilient construction in harsh environments. Further advancements in GFRP production and recycling are recommended to maximize environmental benefits.</p>