<p>Fiber-reinforced concrete (FRC) and advanced confinement techniques play a critical role in the reduction of seismic vulnerability of buildings. While Mander’s and Campione’s models have been widely used to understand confinement behavior in concrete, their system-level implications—particularly in conjunction with fiber-reinforced concrete (FRC)—remain underexplored. The present study discusses the combined impact of confinement methods and fiber-reinforced concrete (FRC) on the seismic vulnerability of a six-storey reinforced concrete (RC) frame building. The seismic performance is assessed through pushover and fragility analyses, comparing normal concrete (modeled using Mander’s model) with FRC (analyzed using Mander’s and Campione’s models). To assess the effectiveness of fiber-reinforced concrete (FRC), critical performance indicators such as structural strength, ductility, damage probability, resilience, functionality, and repair costs are evaluated. Results indicate that FRC significantly enhances seismic performance by increasing overall ductility (up to 55.8%), functionality (up to 20%), and resilience (up to 6.47%). FRC also delays the collapse hinge formation in the building by reducing the Collapse (up to 20%) and extreme (up to 28.2%) damage. Campione’s model generally outperforms Mander’s in ductility and damage reduction, particularly under higher earthquake intensity (MCE conditions). These findings will be helpful for revising Indian Standard (IS) codes to mandate FRC in high-risk seismic zones, improve ductility requirements, and adopt advanced confinement models, thereby improving seismic resilience and lowering long-term costs for Indian infrastructure.</p>