<p>The increasing interest in developing Artificial Intelligence applications in the medical domain, suffers from the lack of high-quality data set, mainly due to privacy-related issues. In addition, the recent increase in Vision Language Models (VLM) leads to the need for multimodal medical data sets, where clinical reports and findings are attached to the corresponding medical scans. This paper illustrates the entire workflow for building the MedPix 2.0 data set. Starting with the well-known multimodal data set MedPix^®, mainly used by physicians, nurses, and healthcare students for Continuing Medical Education purposes, a semi-automatic pipeline was developed to extract visual and textual data followed by a manual curing procedure in which noisy samples were removed, thus creating a MongoDB database. Along with the data set, we developed a Graphical User Interface aimed at navigating efficiently the MongoDB instance and obtaining the raw data that can be easily used for training and/or fine-tuning VLMs. To enforce this point, in this work, we first recall DR-Minerva, a Retrieve Augmented Generation-based VLM model trained upon MedPix 2.0. DR-Minerva predicts the body part and the modality used to scan its input image. We also propose the extension of DR-Minerva with a Knowledge Graph that uses Llama 3.1 Instruct 8B, and leverages MedPix 2.0. The resulting architecture can be queried in an end-to-end manner, as a medical decision support system. MedPix 2.0 is available on GitHub.</p>