Inverse Heat Transfer Method to Control the Cancerous Tissue Temperature During Hyperthermia

One therapeutic method to treat cancer is hyperthermia, in which temperature control is crucial so that only the temperature of the tumor site increases with healthy tissues remaining intact. In regards to the physics governing this phenomenon, the heat transfer equations are of the non-Fourier type. Using inverse heat transfer based on the conjugate gradient method, the present article aims to control the tumor temperature considering the dual-phase lag effect of heat flux and temperature. To increase the tumor temperature up to 42 °C, three different protocols including sinusoidal, triangular and step shape desired temperatures are considered, the results of which revealed that the proposed method can effectively control the tumor temperature with high accuracy during the hyperthermia process. The relative root mean square of the difference between desired and estimated temperatures are 0.51%, 0.69%, and 2.58% for sinusoidal, triangular and step shape desired temperatures, respectively.