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<p>Radionuclides have gained considerable attention in nuclear medicine owing to their broad applications in both therapeutic and diagnostic procedures. Among these, Bromine-76 (<sup>76</sup>Br) is recognized as a reliable positron-emitting radionuclide widely used in Positron Emission Tomography (PET) imaging. The production of <sup>76</sup>Br can be achieved through several charged-particle reactions involving protons, deuterons, helium-3 and alpha particles. In this study, the proton-induced reactions <sup>76</sup>Se(p, n)<sup>76</sup>Br, <sup>77</sup>Se(p, 2n)<sup>76</sup>Br, <sup>78</sup>Se(p, 3n)<sup>76</sup>Br, <sup>79</sup>Se(p, 4n)<sup>76</sup>Br, and <sup>80</sup>Se(p, 5n)<sup>76</sup>Br were investigated through theoretical modeling and Monte Carlo simulations. The excitation functions, proton ranges, theoretical yields, and End-of-Bombardment (EOB) activities were obtained using a combination of nuclear reaction codes and transport simulations. The calculated results were compared with experimental data and the TENDL-2023 nuclear data library, showing good overall agreement and confirming the reliability of the adopted computational approach for modeling <sup>76</sup>Br production.</p>

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Theoretical Study of 76Br Production from Proton-Induced Reactions on Selenium Isotopes for PET Applications

  • 期刊论文

  • 发表日期：

    2026年2月9日

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  • Shatha Alafeshat,
  • Halil Arslan,
  • H. H. Saleh,
  • Baris T. Tonguc

摘要

Radionuclides have gained considerable attention in nuclear medicine owing to their broad applications in both therapeutic and diagnostic procedures. Among these, Bromine-76 (76Br) is recognized as a reliable positron-emitting radionuclide widely used in Positron Emission Tomography (PET) imaging. The production of 76Br can be achieved through several charged-particle reactions involving protons, deuterons, helium-3 and alpha particles. In this study, the proton-induced reactions 76Se(p, n)76Br, 77Se(p, 2n)76Br, 78Se(p, 3n)76Br, 79Se(p, 4n)76Br, and 80Se(p, 5n)76Br were investigated through theoretical modeling and Monte Carlo simulations. The excitation functions, proton ranges, theoretical yields, and End-of-Bombardment (EOB) activities were obtained using a combination of nuclear reaction codes and transport simulations. The calculated results were compared with experimental data and the TENDL-2023 nuclear data library, showing good overall agreement and confirming the reliability of the adopted computational approach for modeling 76Br production.