Scholarlink

<p>This work proposes and implements an approach for designing and manufacturing a bio-inspired thermoplastic polyurethane annulus fibrosus using 3D-printing in a cylindrical coordinate system. The prototype design consists of a set of layered concentric rings with a fiber layout corresponding to the structure of the native lumbar intervertebral disc's annulus fibrosus. Mechanical tests, including static, dynamic, and cyclic compression within a physiological loading range, were conducted on the fabricated samples. The role of a polyacrylamide hydrogel-based nucleus pulposus phantom was demonstrated and thoroughly characterized. It was established that the bio-inspired artificial annulus fibrosus design mimics a nonlinear mechanical response closely resembling that of an intact intervertebral disc under axial compression tests including damping properties. It was experimentally confirmed that, depending on the stiffness of the annulus fibrosus and the testing speed, the nucleus pulposus effectively redistributes and dampens external loads, while having only a marginal effect on the overall compressive load‑bearing characteristics of the hybrid construct, which are governed by the annulus fibrosus architecture.</p> Graphical abstract <p></p>

错误：搜索内容不能为空，请输入英文关键词
错误：关键词超出字数限制，请精简
高级检索

First insights into 3D-printing of biomimetic TPU-made annulus fibrosus with a hydrogel nucleus pulposus: Does fiber orientation matter?

  • 期刊论文

  • 发表日期：

    2026年7月17日

查看全文
  • Nikita Golovkin,
  • Arthur Krupnin,
  • Vsevolod Pobezhimov,
  • Christina Antipova,
  • Sergei Chvalun

摘要

This work proposes and implements an approach for designing and manufacturing a bio-inspired thermoplastic polyurethane annulus fibrosus using 3D-printing in a cylindrical coordinate system. The prototype design consists of a set of layered concentric rings with a fiber layout corresponding to the structure of the native lumbar intervertebral disc's annulus fibrosus. Mechanical tests, including static, dynamic, and cyclic compression within a physiological loading range, were conducted on the fabricated samples. The role of a polyacrylamide hydrogel-based nucleus pulposus phantom was demonstrated and thoroughly characterized. It was established that the bio-inspired artificial annulus fibrosus design mimics a nonlinear mechanical response closely resembling that of an intact intervertebral disc under axial compression tests including damping properties. It was experimentally confirmed that, depending on the stiffness of the annulus fibrosus and the testing speed, the nucleus pulposus effectively redistributes and dampens external loads, while having only a marginal effect on the overall compressive load‑bearing characteristics of the hybrid construct, which are governed by the annulus fibrosus architecture.

Graphical abstract